The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

Musa, Baba Maiyaki; Galadanci, Najibah A.; Coker, Modupe; Bussell, Scottie; Aliyu, Muktar H.

doi:10.1007/s00277-016-2693-z

Cited by 16 publications

(13 citation statements)

References 54 publications

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“…More than 1.5 billion individuals are estimated to currently have hypertension [1–3]. Studies have indicated that blood pressure (BP) values of 120–139/80–89 mm Hg are associated with an increased risk of cardiovascular morbidity and mortality compared with BP levels below 120/80 mm Hg [4–6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Prehypertension and Hypertension in Southern China

et al. 2017

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BackgroundThis study aimed to describe the prevalence and risk factors of prehypertension and hypertension in Jiangxi Province, China. Individuals with prehypertension frequently progress into hypertension and are at high risk of developing cardiovascular disease and stroke.MethodsA cross-sectional survey of 15,296 participants (15 years or older) was conducted in Jiangxi Province, China, in 2013, using questionnaire forms and physical measurements.ResultsThe prevalence of prehypertension and hypertension was 32.3% (39.2% in men and 27.6% in women) and 29.0% (30.1% in men and 28.2% in women), respectively. The awareness, treatment, and control rates among all hypertensive participants were 64.8%, 27.1%, and 12.6%, respectively. The prevalence of prehypertension in males declined with age, but the prevalence of hypertension increased in different genders. The prevalence of prehypertension and hypertension increased with increasing body mass index (BMI). The prevalence of prehypertension decreased, in parallel to an increase in the prevalence of hypertension, with increasing waist circumference (WC). A combination of WC and BMI was superior to individual indices in identifying hypertension. A multivariate logistic regression analysis indicated that increasing age, high BMI, high visceral adipose index, and high heart rate were risk factors for prehypertension and hypertension. The high body fat percentage was significantly associated with prehypertension. Living in an urban area, male sex, abdominal obesity, and menopause were correlated with hypertension.ConclusionsPrehypertension and hypertension are epidemic in southern China. Further studies are needed to explore an indicator that can represent the visceral fat accurately and has a close relationship with cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Prehypertension and Hypertension in Southern China

et al. 2017

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“…Hypertension (HTN) is not only known as a risk factor contributing to cardiovascular disease (CVD) but also a health issue in the community [ 1 ]. The global population currently suffering from HTN are estimated to be more than 1.5 billion people [ 1 – 3 ]. Approximately 7.6 million early deaths were caused to HTN, which was about 13.5% of the global total [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Hypertension in Two Communes in the Vietnam Northern Mountainous, 2017

Van

et al. 2018

BioMed Research International

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Background The aims were to characterize the prevalence of hypertension (HTN) and explore its associations in the northern mountainous. Methods We carried out a cross-sectional study in two communes in Chiem Hoa district, Tuyen Quang province, between June and November 2017. All subjects at the age of 18 years and over currently living in two communes. The usage of the descriptive statistics was to characterize the HTN prevalence. We used the univariate and multivariate models of logistic regression to determine the prevalence and related factors of HTN. ResultsThere were 319 people with overall HTN in the total of 675 participants. Among people with HTN, there were 101 ones with isolated systolic hypertension (ISH). The proportion of HTN among the Tay ethnic group was 47.6%. The factors related to HTN included group, body mass index (BMI), low physical fitness, and waist-hip ratio (WHR). These factors as well as the ethnicity were significantly associated with ISH. Conclusions Two communes of Chiem Hoa district in Tuyen Quang province had a high prevalence of HTN. Age, BMI, WHR, and physical activity were the risk factors of overall HTN and ISH. In particular, ISH was affected by ethnicity.

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“…A systematic review and meta-analysis reported a prevalence of 20.7% in both children and adult patients [ 14 ]. A prospective cohort study revealed that a low forced expiratory volume in one second (FEV1) is associated with early death in SCA [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Sickle Cell Disease Clinical Trials and Phenotypes

Ezekekwu¹,

Kotila²,

Akingbola³

et al. 2018

J Trop Dis

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Sickle cell disease, one of the world’s most common genetic disorders is prevalent in sub-Saharan Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately, migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. Different haplotypes exist, however the differences in these haplotypes are not sufficient to explain the different clinical variations within the same region or different settings.

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The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

Cited by 16 publications

References 54 publications

Prevalence and Risk Factors of Prehypertension and Hypertension in Southern China

Prevalence and Risk Factors of Prehypertension and Hypertension in Southern China

Prevalence and Risk Factors of Hypertension in Two Communes in the Vietnam Northern Mountainous, 2017

Sickle Cell Disease Clinical Trials and Phenotypes

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