The Global Initiative for Children's Surgery: Optimal Resources for Improving Care

Goodman, Libby; St-Louis, Etienne; Yousef, Yasmine; Cheung, Maija; Ure, Benno M.; Ozgediz, Doruk; Ameh, Emmanuel A.; Bickler, Stephen W.; Poenaru, Dan; Oldham, Keith T.; Farmer, Diana L.; Lakhoo, Kokila

doi:10.1055/s-0037-1604399

Cited by 87 publications

(70 citation statements)

References 14 publications

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“…However, there is very limited population-based data from LMICs including Nigeria, and most of the policies have been based on extrapolations from hospital-based studies which are fraught with many inaccuracies. Furthermore, most National Surgical Health Plans have so far not addressed children's surgery [15]. This study provides much-needed data on the burden of paediatric surgical diseases for policy makers in our country.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building

et al. 2019

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Background In many low-and middle-income countries, data on the prevalence of surgical diseases have been derived primarily from hospital-based studies, which may lead to an underestimation of disease burden within the community. Community-based prevalence studies may provide better estimates of surgical need to enable proper resource allocation and prioritization of needs. This study aims to assess the prevalence of common surgical conditions among children in a diverse rural and urban population in Nigeria. Methods Descriptive cross-sectional, community-based study to determine the prevalence of congenital and acquired surgical conditions among children in a diverse rural-urban area of

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Section: Discussionmentioning

confidence: 99%

Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building

et al. 2019

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“…According to the WHO, this proportion could increase to more than 45% by 2030 [3]. The impact appears to be greater for the paediatric population of low-and middle-income countries [6]. In a recent survey, an unmet need for paediatric surgical care was estimated in 62% of children in lowincome countries [7].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological changes in child surgical activity. Analysis of 17 years in a tertiary care hospital in Mexico

Pizarro-Altamirano

Trousselle-Peralta

Soriano-Rosales

et al. 2020

Preprint

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Background: Surgical care is an essential component to achieve universal health coverage. An increase in children's surgical burden is recognized worldwide, but changes in the epidemiological profile associated with global geographic heterogeneity are to be expected. The aims of this study are to analyse the prevalence and epidemiological changes of surgical activity in a tertiary center in Mexico. Methods: Ambispective cohort study. Institutional records were reviewed searching for children’s surgeries in the period comprising 2001-2017. The variables analyzed were age, sex, number of surgeries per subject, and mortality rate; regarding the interventions, kind of inward stay, kind of surgery (ICD 9 CM), ward or department responsible, and perioperative mortality rate (POMR). Results: Of the 104,578 institutional admissions, 37% were surgical procedures of preschool-aged children (30.2%), and infants (27.3%). These tended to decrease, while for adolescents to increase. A total of 84,859 surgeries were performed (1.36 per operating room/day), averaging 4.992 per year, with a marginal tendency to increase. 65.8% of procedures required hospitalization. The systems more frequently intervened were: musculoskeletal system (20.1%, tending to increase), digestive system (19.5%), and cardiovascular system (11.3%). The overall mortality rate of surgical admissions was 5.5%, with POMR of 1.54%. Conclusion: The institutional epidemiological profile has changed, and relevant trends were identified. We corroborated the presence of global geographic heterogeneity with analogous hospitals

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“…In liver transplantation, these technologies have rapidly expanded with multiple devices and systems routinely being used clinically. Normothermic machine perfusion (NMP) has proven to be an exciting technology, with international multicentre randomized control trial data demonstrating its ability to reduce graft injury, prolong preservation and increase utilisation [13,14]. Further studies have reported on sequential SCS and NMP with comparable clinical outcomes to continuous NMP alone, providing robust clinical data in support of the more logistically straightforward 'back to base model' of liver NMP [15].…”

Section: Normothermic Machine Perfusion Of the Livermentioning

confidence: 99%

Normothermic Machine Perfusion (NMP) of the Liver as a Platform for Therapeutic Interventions during Ex-Vivo Liver Preservation: A Review

Dengu

Abbas

Ebeling

et al. 2020

JCM

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Liver transplantation is increasingly dependent on the use of extended criteria donors (ECD) to increase the organ donor pool and address rising demand. This has necessitated the adoption of innovative technologies and strategies to protect these higher-risk grafts from the deleterious effects of traditional preservation and ischaemia reperfusion injury (IRI). The advent of normothermic machine perfusion (NMP) and rapid growth in the clinical adoption of this technology has accelerated efforts to utilise NMP as a platform for therapeutic intervention to optimise donor livers. In this review we will explore the emerging preclinical data related to ameliorating the effects of IRI, protecting the microcirculation and reducing the immunogenicity of donor organs during NMP. Exploiting the window of opportunity afforded by NMP, whereby the liver can be continuously supported and functionally assessed while therapies are directly delivered during the preservation period, has clear logistical and theoretical advantages over current preservation methods. The clinical translation of many of the therapeutic agents and strategies we will describe is becoming more feasible with widespread adaptation of NMP devices and rapid advances in molecular biology and gene therapy, which have substantially improved the performance of these agents. The delivery of novel therapeutics during NMP represents one of the new frontiers in transplantation research and offers real potential for successfully tackling fundamental challenges in transplantation such as IRI.

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The Global Initiative for Children's Surgery: Optimal Resources for Improving Care

Cited by 87 publications

References 14 publications

Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building

Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building

Epidemiological changes in child surgical activity. Analysis of 17 years in a tertiary care hospital in Mexico

Normothermic Machine Perfusion (NMP) of the Liver as a Platform for Therapeutic Interventions during Ex-Vivo Liver Preservation: A Review

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