The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Borrow, Ray; Alarcón, Pedro; Carlos, Josefina; Caugant, Dominique A.; Christensen, Hannah; Debbag, Roberto; Wals, Philippe De; Echániz-Avilés, Gabriela; Findlow, Jamie; Head, Chris; Holt, Daphné; Kamiya, Hajime; Saha, Samir K.; Сидоренко, С. В.; Taha, Muhamed‐Kheir; Trotter, Caroline; Moreno, Julio A. Vázquez; Gottberg, Anne von; Sáfadi, Marco Aurélio Palazzi

doi:10.1080/14760584.2017.1258308

Cited by 213 publications

(256 citation statements)

References 79 publications

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“…Our isolates were predominantly serogroup B, with only two patients with strains from serogroup C. This is consistent with previous reports of serogroup B isolates causing sporadic disease in Thailand (Pancharoen et al 2000;Borrow et al 2017) while very little information is available about common serogroups in Laos and Cambodia. The serogroup B and serogroup C strains were not separated in the phylogeny, suggesting a capsule switch may have occurred in these strains.…”

Section: Discussionsupporting

confidence: 93%

The spread of chloramphenicol-resistantNeisseria meningitidisin Southeast Asia

Batty

Cusack

Thaipadungpanit

et al. 2019

Preprint

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AbstractInvasive disease caused by Neisseria meningitidis is a significant health concern globally, but our knowledge of the prevailing serogroups, antimicrobial susceptibility patterns, and genetics of N. meningitidis in Southeast Asia is limited. Chloramphenicol resistance in N. meningitidis has rarely been reported, but was first described in isolates from Vietnam in 1998. Using whole-genome sequencing of meningococcal isolates from 18 patients collected between 2007 and 2018 from diagnostic microbiology laboratories in Cambodia, Thailand and the Lao People’s Democratic Republic (Laos), of which eight were non-susceptible to chloramphenicol, we report the spread of this chloramphenicol-resistant lineage of N. meningitidis across Southeast Asia. Strains resistant to penicillin, tetracycline, and ciprofloxacin were also observed, including a chloramphenicol-resistant strain from the previously-described lineage which has acquired penicillin and ciprofloxacin resistance, and most isolates were of serogroup B. This study suggests that chloramphenicol-resistant N. meningitidis is more widespread than previously thought.

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Section: Discussionsupporting

confidence: 93%

The spread of chloramphenicol-resistantNeisseria meningitidisin Southeast Asia

Batty

Cusack

Thaipadungpanit

et al. 2019

Preprint

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“…Of the 13 meningococcal capsular serogroups described, six (A, B, C, W, X, Y) are associated with the majority of disease 1 . Capsular polysaccharide based vaccines against serogroups A, C, W and Y, and an outer membrane protein based vaccine for serogroup B are available 2 . These vaccines are not universally administered and there is no serogroup X vaccine, leaving several populations susceptible to meningococcal disease.…”

Section: Introductionmentioning

confidence: 99%

The glycointeractome of serogroup B Neisseria meningitidis strain MC58

Mubaiwa

Hartley-Tassell

Semchenko

et al. 2017

Sci Rep

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Neisseria meningitidis express numerous virulence factors that enable it to interact with diverse microenvironments within the host, during both asymptomatic nasopharyngeal colonization and invasive disease. Many of these interactions involve bacterial or host glycans. In order to characterise the meningococcal glycointeractome, glycan arrays representative of structures found on human cells, were used as a screening tool to investigate host glycans bound by N. meningitidis. Arrays probed with fluorescently labelled wild-type MC58 revealed binding to 223 glycans, including blood group antigens, mucins, gangliosides and glycosaminoglycans. Mutant strains lacking surface components, including capsule, lipooligosaccharide (LOS), Opc and pili, were investigated to identify the factors responsible for glycan binding. Surface plasmon resonance and isothermal calorimetry were used to confirm binding and determine affinities between surface components and host glycans. We observed that the L3 LOS immunotype (whole cells and purified LOS) bound 26 structures, while L8 only bound 5 structures. We further demonstrated a direct glycan-glycan interaction between purified L3 LOS and Thomsen–Friedenreich (TF) antigen, with a KD of 13 nM. This is the highest affinity glycan-glycan interaction reported to date. These findings highlight the diverse glycointeractions that may occur during different stages of meningococcal disease, which could be exploited for development of novel preventative and therapeutic strategies.

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“…7,8 In contrast, the "meningitis belt" of sub-Saharan Africa has historically reported frequent epidemics of MD, but the incidence had fallen 10-fold by 2013, following the introduction of the serogroup A (MenA) vaccine in 2010; cases of MenC, W, and X are also reported in this region. 8,9 The World Health Organization (WHO) has reported 26,029 meningitis cases in the African meningitis belt in 2016 with 2080 deathsdan overall casefatality ratio of 8.0%. 10 Only half of the laboratory-confirmed cases were caused by meningococci, while for the great majority of the samples the causative organism was not identified.…”

Section: Introductionmentioning

confidence: 99%