The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis

Salari, Nader; Ghasemi, Hooman; Mohammadi, Loghman; Behzadi, Mohammad Hassan; Rabieenia, Elham; Shohaimi, Shamarina; Mohammadi, Masoud

doi:10.1186/s13018-021-02772-0

Cited by 442 publications

(280 citation statements)

References 81 publications

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“…Based on a meta-analysis conducted worldwide and reviewing 86 studies with a sample size of 103,334,579 in the age range of 15 to 105 years, it was reported that the prevalence of osteoporosis in the world is 18.3% [ 68 ], which shows a high prevalence, while age is a high-risk factor for osteoporosis and Vitamin D insufficiency and reduced calcium absorption are common in the elderly [ 69 , 70 ]. Osteoporosis is increasing due to increased life expectancy and an aging population [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis

et al. 2021

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Background Osteoporosis is one of the most common bone system diseases that is associated with an increased risk of bone fractures and causes many complications for patients. With age, the prevalence of this disease increases so that it has become a serious problem among the elders. In this study, the prevalence of osteoporosis among elders around the world is examined to gain an understanding of its prevalence pattern. Methods In this systematic review and meta-analysis, articles that have focused on prevalence of osteoporosis in the world’s elders were searched with these key words, such as Prevalence, Osteoporosis, Elders, Older adult in the Science Direct, Embase, Scopus, PubMed, Web of Science (WoS) databases and Google Scholar search engine, and extracted without time limit until March 2020 and transferred to information management software (EndNote). Then, duplicate studies were eliminated and the remaining studies were evaluated in terms of screening, competence and qualitative evaluation based on inclusion and exclusion criteria. Data analysis was performed with Comprehensive Meta-Analysis software (Version 2) and Begg and Mazumdar test was used to check the publication bias and I2 test was used to check the heterogeneity. Results In a review of 40 studies (31 studies related to Asia, 5 studies related to Europe and 4 studies related to America) with a total sample size of 79,127 people, the prevalence of osteoporosis in the elders of the world; 21.7% (95% confidence interval: 18.8–25%) and the overall prevalence of osteoporosis in older men and women in the world, 35.3% (95% confidence interval: 27.9–43.4%), 12.5% (95% confidence interval: 9.3–16.7%) was reported. Also, the highest prevalence of osteoporosis in the elders was reported in Asia with; 24.3% (95% confidence interval: 20.9–28.1%). Conclusion The results of the present study showed that the prevalence of osteoporosis in the elders and especially elders' women is very high. Osteoporosis was once thought to be an inseparable part of elders’ lives. Nowadays, Osteoporosis can be prevented due to significant scientific advances in its causes, diagnosis, and treatment. Regarding the growing number of elderly people in the world, it is necessary for health policy-makers to think of measures to prevent and treat osteoporosis among the elders.

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Section: Discussionmentioning

confidence: 99%

Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis

et al. 2021

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“…Herein we have prepared cAp and cAp-Tb nanoparticles and investigated their loading/release ability of DF, a potent non-steroidal antiinflammatory drug, using both nanocarriers in different conditions, and we have analyzed their cytocompatibility as well as their biological activities in an in vitro human osteoblast inflammation model. Indeed, today bone tissue pathologies, such as osteoporosis, osteoarthritis, rheumatoid arthritis represent important health problems with considerable socio-economic burden, linked to the general population aging [ 8 , 9 ] and are all characterized by a clinical condition of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…From the other side, also the nature/composition of the nanocarrier can vary depending on the diseases to be treated. Today bone tissue pathologies, such as osteoporosis, osteoarthritis and rheumatoid arthritis represent important health problems with considerable socio-economic burden, linked to the general population aging [ 8 , 9 ]. These musculo-skeletal disorders are characterized by a clinical condition of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

et al. 2022

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Luminescent nanoparticles are innovative tools for medicine, allowing the imaging of cells and tissues, and, at the same time, carrying and releasing different types of molecules. We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40 °C) and pHs (7.4, 5.2). The cytocompatibility was evaluated on two osteosarcoma cell lines and primary human osteoblasts. Biological effects of diclofenac-loaded-nanoparticles were monitored in an in vitro osteoblast’s cytokine–induced inflammation model by evaluating COX-2 mRNA expression and production of PGE2. Adsorption isotherms fitted the multilayer Langmuir-Freundlich model. The maximum adsorbed amounts at 37 °C were higher than at 25 °C, and particularly when using the Tb3+ -doped particles. Diclofenac-release efficiencies were higher at pH 5.2, a condition simulating a local inflammation. The luminescence properties of diclofenac-loaded Tb3+ -doped particles were affected by pH, being the relative luminescence intensity higher at pH 5.2 and the luminescence lifetime higher at pH 7.4, but not influenced either by the temperature or by the diclofenac-loaded amount. Both undoped and Tb3+-doped nanoparticles were cytocompatible. In addition, diclofenac release increased COX-2 expression and decreased PGE2 production in an in vitro inflammation model. These findings evidence the potential of these nanoparticles for osteo-localized delivery of anti-inflammatory drugs and the possibility to localize the inflammation, characterized by a decrease in pH, by changes in luminescence.

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“…By 2050, hip fractures may exceed 21 million cases [1]. The prevalence of osteoporosis is 18.3% globally, and it is greater in women than in men (23.1 and 11.7, respectively) [4]. The direct cost of treating these osteoporotic fractures in five European countries (France, Germany, the United Kingdom, Italy and Spain) is EUR 29 billion, while for the 27 EU Member States as a whole it is EUR 38.7 billion, a cost that is expected to increase by 25% until 2025 [5].…”

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Exercise and Nutrition Impact on Osteoporosis and Sarcopenia—The Incidence of Osteosarcopenia: A Narrative Review

et al. 2021

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Osteoporosis and sarcopenia are diseases which affect the myoskeletal system and often occur in older adults. They are characterized by low bone density and loss of muscle mass and strength, factors which reduce the quality of life and mobility. Recently, apart from pharmaceutical interventions, many studies have focused on non-pharmaceutical approaches for the prevention of osteoporosis and sarcopenia with exercise and nutrition to being the most important and well studied of those. The purpose of the current narrative review is to describe the role of exercise and nutrition on prevention of osteoporosis and sarcopenia in older adults and to define the incidence of osteosarcopenia. Most of the publications which were included in this review show that resistance and endurance exercises prevent the development of osteoporosis and sarcopenia. Furthermore, protein and vitamin D intake, as well as a healthy diet, present a protective role against the development of the above bone diseases. However, current scientific data are not sufficient for reaching solid conclusions. Although the roles of exercise and nutrition on osteoporosis and sarcopenia seem to have been largely evaluated in literature over the recent years, most of the studies which have been conducted present high heterogeneity and small sample sizes. Therefore, they cannot reach final conclusions. In addition, osteosarcopenia seems to be caused by the effects of osteoporosis and sarcopenia on elderly. Larger meta-analyses and randomized controlled trials are needed designed based on strict inclusion criteria, in order to describe the exact role of exercise and nutrition on osteoporosis and sarcopenia.

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The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis

Cited by 442 publications

References 81 publications

Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis

Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

Exercise and Nutrition Impact on Osteoporosis and Sarcopenia—The Incidence of Osteosarcopenia: A Narrative Review

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