The Global Prevalence of Schistosoma mansoni, S. japonicum, and S. haematobium in Pregnant Women: A Systematic Review and Meta-Analysis

Cando, Leslie Faye T.; Perias, Glenmarie Angelica S.; Tantengco, Ourlad Alzeus G.; Dispo, Micah D.; Ceriales, Jeremy A.; Girasol, Mark John G.; Leonardo, Lydia; Tabios, Ian Kim B.

doi:10.3390/tropicalmed7110354

Cited by 10 publications

(10 citation statements)

References 56 publications

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“…The prevalence of S. haematobium reported in the present study was higher than the mean global prevalence of 13.44% during pregnancy estimated from various countries worldwide [33]. Our prevalence was similar to that reported among Nigeria pregnant women [34] while it's higher than previously reported values in other countries such as Cameroon [10], Tanzania [35] where prevalence were less than 5%.…”

Section: Discussionsupporting

confidence: 72%

Prevalence and risk factors of schistosomiasis among pregnant women in northern Senegal

Ndiour,

Senghor,

Thiam

et al. 2023

Preprint

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Background Schistosomiasis remains a public health concern worldwide. It is responsible for more than 240 million cases in 78 countries, 40 million of whom are women of childbearing age. In the Senegal River basin, both Schistosoma haematobium and Schistosoma mansoni are very prevalent in school-age children. However, there is a lack of information on burden of schistosomiasis in pregnant women, which can cause complications for the pregnancy outcome. The aim of this study was to determine the prevalence and risk factors associated with infection in pregnant women. Methods We conducted a prospective cross-sectional study of pregnant women attending antenatal clinics at the health center of the Senegalese sugar company and at the hospital of Richard Toll between August and December 2021. The urine and stool samples collected were examined using microscopy techniques and quantitative polymerase chain reaction (qPCR) to detect the presence of S. haematobium and S. mansoni. Urine were previously tested using urine reagent strips to detect hematuria and proteinuria. Sociodemographic, clinical and biological data were collected from each participant. The data were analyzed using logistic regression model. Results Among the 298 women examined for the infection by microscopic, 65 (21.81%) were infected with urogenital schistosomiasis, 10 (3.36%) with intestinal schistosomiasis and 4 (1.34%) were co-infected with both types of schistosomiasis. Out of the 288 samples tested by qPCR, 146 (48.99%) were positive for S. haematobium, 49 (35.51%) for S. mansoni and 22 (15.94%) for both species (co-infection). Schistosomiasis was significantly associated with the presence of blood and the protein on strips (p < 0.05). Conclusion This study has revealed a high prevalence of schistosomiasis in pregnant women in Senegal. The qPCR allowed us to detect more cases compared to the microscopy. There is a need to conduct more studies to understand the real burden of the disease and to set up a surveillance system to prevent pregnancy-related complications.

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Section: Discussionsupporting

confidence: 72%

Prevalence and risk factors of schistosomiasis among pregnant women in northern Senegal

Ndiour,

Senghor,

Thiam

et al. 2023

Preprint

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“…4 ) [ 81 ]. Petukhova and colleagues have used cryo-electron microscopy to identify a new class of inhibitors for thioredoxin glutathione reductase, an essential schistosomal enzyme [ 82 ]. These inhibitors have the potential to be developed into new anti-schistosomal drugs, as they impair the parasite's survival in the host by inhibiting the enzyme.…”

Section: Current Therapies and Additional Strategies To Be Consideredmentioning

confidence: 99%

“…These inhibitors have the potential to be developed into new anti-schistosomal drugs, as they impair the parasite's survival in the host by inhibiting the enzyme. The compounds demonstrated schistosomicidal activity against various stages of the parasite and were effective in treating schistosome infections in mice [ 82 ]. They were found to be more effective than praziquantel in treating young worms and meet the WHO criteria for progressive parasitemia [ 82 ].…”

Section: Current Therapies and Additional Strategies To Be Consideredmentioning

confidence: 99%

“…The compounds demonstrated schistosomicidal activity against various stages of the parasite and were effective in treating schistosome infections in mice [ 82 ]. They were found to be more effective than praziquantel in treating young worms and meet the WHO criteria for progressive parasitemia [ 82 ]. Molehin et al.…”

Section: Current Therapies and Additional Strategies To Be Consideredmentioning

confidence: 99%

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Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis

Ponzo,

Midiri,

Manno

et al. 2024

EuJMI

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Schistosomiasis is a neglected tropical disease that is prevalent in low- and middle-income countries. There are five human pathogenic species, of which Schistosoma haematobium, Schistosoma mansoni and Schistosoma japonicum are the most prevalent worldwide and cause the greatest burden of disease in terms of mortality and morbidity. In addition, hybrid schistosomes have been identified through molecular analysis. Human infection occurs when cercariae, the larval form of the parasite, penetrate the skin of people while bathing in contaminated waters such as lakes and rivers. Schistosomiasis can cause both urogenital and intestinal symptoms. Urogenital symptoms include haematuria, bladder fibrosis, kidney damage, and an increased risk of bladder cancer. Intestinal symptoms may include abdominal pain, sometimes accompanied by diarrhoea and blood in the stool. Schistosomiasis affects more than 250 million people and causes approximately 70 million Disability-Adjusted Life Years (DALYs), mainly in Africa, South America, and Asia. To control infection, it is essential to establish sensitive and specific diagnostic tests for epidemiological surveillance and morbidity reduction. This review provides an overview of schistosomiasis, with a focus on available diagnostic tools for Schistosoma spp. Current molecular detection methods and progress in the development of new diagnostics for schistosomiasis infection are also discussed.

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“…Roughly 40 million of women of childbearing age are estimated to be infected with schistosomes, with over 10 million women in Africa contracting the infection during pregnancy, mainly associated with S. haematobium [ 66 ]. Unfortunately, the literature lacks substantial data on infection prevalence among pregnant women and newborns [ 67 , 68 , 69 ].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Female Genital Schistosomiasis: A Neglected among the Neglected Tropical Diseases

Rossi,

Previtali,

Salvi

et al. 2024

Microorganisms

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Schistosomiasis is a neglected parasitic disease linked to water, posing a global public health concern with a significant burden in sub-Saharan Africa. It is transmitted by Schistosoma spp., causing both acute and chronic effects affecting the urogenital or the hepato-intestinal system. Through granuloma formation, chronic schistosomiasis weakens host immunity, heightening susceptibility to coinfections. Notably, female genital schistosomiasis (FGS), a disregarded gynecological condition, adversely affects girls’ and women’s reproductive health and increases vulnerability to HIV. This review explores the intricate interplay between schistosomiasis and HIV, considering their geographical overlap. We delve into the clinical features of this coinfection, underlying mutual influences on transmission, diagnostic challenges, and therapeutic approaches. Understanding the dynamics of FGS and HIV coinfection is pivotal for integrated healthcare strategies in regions with co-endemicity, aiming to mitigate the impact of the two infections on vulnerable populations.

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The Global Prevalence of Schistosoma mansoni, S. japonicum, and S. haematobium in Pregnant Women: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 56 publications

Prevalence and risk factors of schistosomiasis among pregnant women in northern Senegal

Prevalence and risk factors of schistosomiasis among pregnant women in northern Senegal

Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis

Female Genital Schistosomiasis: A Neglected among the Neglected Tropical Diseases

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