The global profile of antibiotic resistance in bacteria isolated from goats and sheep: A systematic review

Herawati, Okti; Bejo, Siti Khairani; Zakaria, Zunita; Ramanoon, Siti Zubaidah

doi:10.14202/vetworld.2023.977-986

Cited by 3 publications

(2 citation statements)

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“…Despite this, cephalothin remains a preferable antibiotic choice against Gram-positive bacteria. In a previous study (Herawati et al, 2023), Gram-negative bacteria, including Salmonella and E. coli, isolated from goats and sheep, were found to display resistance to ampicillin, tetracycline, cephalothin, and gentamycin.…”

Section: Discussionmentioning

confidence: 94%

Antibiogram profiles of pathogenic and commensal bacteria in goat and sheep feces on smallholder farm

Basnet,

Kilonzo-Nthenge

2024

Front. Antibiot.

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IntroductionThe increase of antimicrobial resistance (AMR) in zoonotic pathogens poses a substantial threat to both animal production and human health. Although large-scale animal farms are acknowledged as major reservoirs for AMR, there is a notable knowledge gap concerning AMR in small-scale farms. This study seeks to address this gap by collecting and analyzing 137 fecal samples from goat and sheep farms in Tennessee and Georgia.MethodBacteria were identified using culture-dependent methods and polymerase chain reaction (PCR), and antimicrobial susceptibility testing (AST) was performed using the Kirby-Bauer Disk Diffusion method.Results and discussionThe prevalence of E. coli (94.9%) in goats and sheep significantly exceeded (p < 0.05) that of S. aureus (81.0%), Shigella (35.0%), S. saprophyticus, and Salmonella (3.0%). Salmonella occurrence in goat feces (2.2%) was higher than in sheep (0.8%). Notably, 27% of goats and 8% of sheep tested positive for Shigella spp., while 60% of goats and 21% of sheep tested positive for S. aureus. Antibiotic resistance was observed primarily against ampicillin (79.4%), vancomycin (65.1%), and gentamycin (63.6%), significantly surpassing (p < 0.05) resistance to tetracycline (41.6%) and imipenem (21.8%). The penicillin (79.4%), glycopeptide (65.1%), and aminoglycoside (63.6%) antibiotic classes displayed significantly higher (p < 0.05) resistance compared to tetracyclines (45.7%) and carbapenem (21.8%). Our findings suggest that goats and sheep feces may serve as source for multidrug-resistant bacteria, raising concerns about the potential introduction of their fecal matter into soil, water, and eventually to the food chain. This highlights the need for proactive measures to address and mitigate AMR in goats and sheep within small-scale farms.

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Section: Discussionmentioning

confidence: 94%

Antibiogram profiles of pathogenic and commensal bacteria in goat and sheep feces on smallholder farm

Basnet,

Kilonzo-Nthenge

2024

Front. Antibiot.

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“…The overuse of antibiotics in animal treatment and productivity enhancement has led to a significant increase in antibiotic resistance [ 14 ]. This is particularly relevant for tetracyclines, which have been extensively used in veterinary therapy, prevention, and growth promotion in pigs, among others [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Antimicrobial Resistance in Escherichia coli Strains Isolated From Swine, Poultry, and Farm Workers in the Respective Livestock Farming Units in Greece

Christodoulou

2023

Cureus

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Human health is at risk because commensal intestinal bacteria in livestock have been developing increased antibiotic resistance, mainly due to antibiotics' extensive use in recent years. In this study, we compared the antibiotic resistance of E. coli strains isolated from fecal samples obtained from swine, poultry, and farm workers in the corresponding livestock farming units. The study aimed to investigate the correlation between the antibiotic resistance patterns of E. coli in livestock and in humans closely interacting with them. Antibiotic resistance is determined using the microdilution method, which measures the minimum inhibitory concentration (MIC) for seven commonly used antimicrobial agents. Most E. coli isolates displayed significant resistance to tetracycline and ampicillin. Resistance to sulfamethoxazole was observed, too, in swine and swine farmers. In contrast, high resistance rates to nalidixic acid were observed in E. coli strains isolated from poultry and poultry farmers, with percentages of 66.7% and 50%, respectively. Furthermore, 31.57% of the isolated strains from swine and swine farmers were resistant to at least one antibiotic. In comparison, 44.44% of the poultry strains and 33.33% of the poultry farmers' strains were resistant to at least two antibiotics. Additionally, a high prevalence of multidrug resistance was observed among the E. coli strains isolated from all four categories. The study's results provide evidence that the use of antibiotics and the increased resistance of intestinal bacteria affect the resistance of intestinal bacteria in people working on farms. These findings highlight the potential role of antibiotic use in animals as a contributing factor to the development of antibiotic resistance in both animals and humans. Additionally, it suggests that individuals working on farms may be at an increased risk of acquiring antibiotic-resistant strains of E. coli due to their proximity to and interaction with animals.

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Antimicrobial resistance profiles of Escherichia coli derived from an integrated agroforestry-livestock system in Deli Serdang Regency, Indonesia

Dewi,

Nuryawan,

Jajere

et al. 2024

Vet World

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Background and Aim: Antimicrobial resistance (AMR) has become a significant global concern. Epidemiological data do not provide a robust description of the potential risks associated with AMR in the integrated agroforestry-livestock systems in Indonesia. Thus, the present study investigated the phenotypic and multidrug resistance (MDR) profiles of Escherichia coli strains isolated from the feces of livestock raised in the agro-silvopastoral system in Deli Serdang Regency, North Sumatra Province. Materials and Methods: A standard microbiological culture procedure was followed to isolate the organism and test antibiotic susceptibility using the Kirby-Bauer disk diffusion protocol. Furthermore, the multiple antibiotic resistance index was determined. Univariate analysis was conducted to identify the risk factors associated with AMR. Results: The vast majority (77.5%) of livestock farmers were aged >30 years. All farmers were men and had no higher education (100% of them). The majority of the animal species managed were cattle and goats (37.5% each) and the livestock grazing pasture system (67.5%). In addition, the majority of farmers reported high antimicrobial use on their farms (87.5%). Of the samples (n = 142) analyzed, n = 70 were positive, with an overall prevalence of 44.4%. The species-specific prevalences of E. coli were 32.5%, 47.8%, and 50% in buffalo, goat, and cattle, respectively. Ampicillin and tetracyclines exhibited high resistance levels among the studied animal species. A relatively lower MDR for E. coli was associated with grazing on the pasture. Conclusion: The findings from the current study provide baseline epidemiological information for future robust studies aimed at elucidating the drivers and patterns of AMR in agro-silvopastoral systems in the study area or elsewhere. Keywords: agro-silvopastoral, antimicrobial Resistance, Escherichia coli,Indonesia, livestock, multidrug resistance.

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The global profile of antibiotic resistance in bacteria isolated from goats and sheep: A systematic review

Cited by 3 publications

References 66 publications

Antibiogram profiles of pathogenic and commensal bacteria in goat and sheep feces on smallholder farm

Antibiogram profiles of pathogenic and commensal bacteria in goat and sheep feces on smallholder farm

Comparison of Antimicrobial Resistance in Escherichia coli Strains Isolated From Swine, Poultry, and Farm Workers in the Respective Livestock Farming Units in Greece

Antimicrobial resistance profiles of Escherichia coli derived from an integrated agroforestry-livestock system in Deli Serdang Regency, Indonesia

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