The global, regional, and national disease burden of breast cancer attributable to low physical activity from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019

Yin, Xiaolin; Zhang, Tongchao; Zhang, Yuan; Man, Jinyu; Yang, Xiaorong; Lü, Ming

doi:10.1186/s12966-022-01283-3

Cited by 18 publications

(16 citation statements)

References 41 publications

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“…FBC was defined according to the International Classification of Diseases (ICD)-10 code as C50-C50.9, D05-D05.9, D24-D24.9, D48.6, and D49.3, as well as according to the ICD-9 code as 174-175.9, 217-217.8, 233.0, 238.3, 239.3, and 610-610.9 (12).…”

Section: Methodsmentioning

confidence: 99%

“…The aims of the present study were the following: To determine the incidence, mortality, and burden of FBC; To compare the incidence, mortality, and burden of FBC based on different classifications; To determine associations between age-standardized incidence rates and age-standardized mortality rates of FBC with smoking, drinking, and drug use. FBC was defined according to the International Classification of Diseases (ICD)-10 code as C50-C50.9, D05-D05.9, D24-D24.9, D48.6, and D49.3, as well as according to the ICD-9 code as 174–175.9, 217–217.8, 233.0, 238.3, 239.3, and 610–610.9 ( 12 ).…”

Section: Methodsmentioning

confidence: 99%

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The Global Incidence, Mortality, and Burden of Breast Cancer in 2019: Correlation With Smoking, Drinking, and Drug Use

et al. 2022

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BackgroundFemale breast cancer (FBC) is the most common type of cancer and is associated with a considerable disease burden as well as significant mortality rates. The present study aimed to provide an update on the incidence, mortality, and burden of FBC in 2019, based on the Global Burden of Disease (GBD) Study.MaterialsThe incidence, death rate, disability-adjusted life years (DALYs), years of life lost (YLLs), years lived with disability (YLDs), the age-standardized rates (ASR) of FBC in 204 countries, and a variety of classifications, were retrieved from the Global Burden of Disease Study. Data on tobacco use, alcohol consumption, and drug use were collected. The incidence, mortality, and burden of FBC were registered and compared between regions. Associations between age-standardized incidence rates and age-standardized mortality rates of FBC with smoking, drinking, and drug use were determined.ResultsThe highest incidence of FBC was observed in countries with a high socioeconomic status such as those of the European continent. Despite the lower incidence of FBC in countries with a low socio-demographic index (SDI), mortality rates secondary to FBC are higher in these countries than in high-income countries. The highest age-standardized mortality rate has been reported in the Eastern Mediterranean Region (EMRO), followed by the African Region (AFRO). The highest age-standardized rates of DALY and YLL per 100,000 population in 2019 were observed in lower-income countries, while the highest ASR of YLD per 100,000 population was reported in high-income countries.ConclusionThe present GBD-based study provides a comprehensive review of the incidence, mortality, and burden of FBC in 2019. The incidence of FBC is higher in regions with a higher socioeconomic status, whereas mortality rates and DALYs are higher in poorly developed regions. We suggest better screening measures and early detection programs for the latter regions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Global Incidence, Mortality, and Burden of Breast Cancer in 2019: Correlation With Smoking, Drinking, and Drug Use

et al. 2022

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“…Among European women, approximately 6.8% of the patients and 2.0% of the controls had protein-truncating variants in any of the 9 genes associated with breast cancer risk; in addition, 2.2% of the patients and 1.4% of the controls had missense variants in CHEK2. The frequency of protein-truncating variants among Asian women (4.4% of the patients and 1.3% of the controls) was lower than the frequency among European women; this finding is attributable to the much lower frequency of the c.1100delC variant in CHEK2 among Asian women [1]. Moreover, Tuberculosis is the third major fatal disease rapidly growing worldwide and its resistance to potential therapeutics has become a huge threat to humankind.…”

Section: Introductionmentioning

confidence: 89%

Molecular Docking Study of Hentriacontane for Anticancer and Antitubercular Activity

Madriwala

B.V.²,

JAYS³

2022

Int J Chem Res

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Objective: The present study discusses the molecular docking study of Hentriacontane for its Anti-tubercular and Anti-cancer activity. Methods: Two protein targets were selected for the study and their structures were taken from RCSB Protein Data Bank in PDB format. Preparation of proteins was done using Discovery Studio 2021 Client. The structure of Hentriacontane was drawn using ChemDraw 20.0 and saved in Mol format. Molecular docking was performed using PyRx software. 3D and 2D docking interactions were visualized by Discovery Studio 2021 Client. Results: Hentriacontane has docked against the selected proteins, namely Extra-cellular regulated kinase–2 (ERK-2; PDB ID: 3QYW) and Shikimate kinase (PDB ID: 1ZYU). The compound has shown the best binding score against Shikimate kinase (-10.4 kcal/mol), and Extra-cellular regulated kinase–2 (-7.4 kcal/mol) than the standard drugs. Conclusion: Molecular Docking study indicates that Hentriacontane could be an effective inhibitor for the proteins under study. Hence, the compound may be considered a lead molecule and further investigation of its analogues may help in the development of novel drugs for the treatment of breast cancer and tuberculosis.

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“…According to the METs, physical activity was classified into four levels: inactive (<600 MET-minutes per week), slightly active (600-3,999 MET-minutes per week), moderately active (4,000-7,999 MET-minutes per week), and highly active (≥8,000 MET-minutes per week). LPA was defined as < 3,000 MET-min per week (14) The measure of disease attributable to low physical activity…”

Section: The Measure and Definition Of Low Physical Activitymentioning

confidence: 99%

The Global Burden of Disease attributable to low physical activity and its trends from 1990 to 2019: An analysis of the Global Burden of Disease study

Xie

Yin

et al. 2022

Front. Public Health

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IntroductionLow physical activity (LPA) is associated with several major non-communicable diseases (NCDs) and premature mortality. In this study, we aimed to assess the global burden and trends in disease attributable to LPA (DALPA) from 1990 to 2019.MethodsAnnual age-standardized disability-adjusted life years (DALYs) and death rates of DALPA [all-cause and five specific causes (ischaemic heart disease, diabetes mellitus, stroke, colon and rectal cancer, and breast cancer)] by sex, age, geographical region and social deprivation index (SDI) score from 1990 to 2019 were available from the Global Burden of Disease (GBD) study 2019. The estimated annual percentage changes (EAPCs) were calculated to quantify the changing trend. A generalized linear model (GLM) was used to explore the relationship between DALYs/death rates of DALPA and sociodemographic factors.ResultsGlobally, in 2019, the age-standardized DALYs and death rates of DALPA were 198.42/100,000 (95% UI: 108.16/100,000–360.32/100,000) and 11.10/100,000 (95% UI: 5.66/100,000–19.51/100,000), respectively. There were 15.74 million (8.51–28.61) DALYs and 0.83 million (0.43–1.47) deaths attributable to LPA. Overall, age-standardized DALYs and death rates presented significant downward trends with EAPCs [−0.68% (95% CI: −0.85– −0.50%) for DALYs and −1.00% (95% CI: −1.13– −0.86%) for deaths] from 1990 to 2019. However, age-standardized DALYs and death rates of diabetes mellitus attributable to LPA were substantially increased [EAPC: 0.76% (95% CI: 0.70–0.82%) for DALYs and 0.33% (95% CI: 0.21–0.51%) for deaths]. In the 15–49 age group, DALPA presented significant upward trends [EAPC: 0.74% (95% CI: 0.58–0.91%) for DALYs and 0.31% (95% CI: 0.1–0.51%) for deaths]. The GLM revealed that higher gross domestic product and current health expenditure (% of GDP) were negatively associated with DALYs and death rates of DALPA.ConclusionAlthough global age-standardized DALYs and death rates of DALPA presented downward trends, they still cause a heavy burden worldwide. These rates showed upward trends in the diabetic and 15–49 age groups, which need more attention and health interventions.

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The global, regional, and national disease burden of breast cancer attributable to low physical activity from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019

Cited by 18 publications

References 41 publications

The Global Incidence, Mortality, and Burden of Breast Cancer in 2019: Correlation With Smoking, Drinking, and Drug Use

The Global Incidence, Mortality, and Burden of Breast Cancer in 2019: Correlation With Smoking, Drinking, and Drug Use

Molecular Docking Study of Hentriacontane for Anticancer and Antitubercular Activity

The Global Burden of Disease attributable to low physical activity and its trends from 1990 to 2019: An analysis of the Global Burden of Disease study

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