This article provides an overview of theoretical and empirical efforts to understand the multiple dimensions enabling and hindering (transnational) labour organising in the context of globalised production. It situates the contributions to this special issue in the broader debate on the role of labour and workers' agency in global value chains and production networks. For this, it brings together chain and network approaches with labour studies in a highly productive dialogue. Focusing on labour as a transnational actor, the article further identifies different approaches of and actors within transnational organising and provides empirical insights on the complexity of the politics of scale in organising efforts. Four key issues are identified as complicating labour organising along global value chains: (i) asymmetrical power relations within organising, particularly between the global North and South, (ii) the continued importance of the local and national scale, (iii) difference and dividing lines between workers, and (iv) the red-green divide. The article argues for the importance of a multi-scalar and intersectional perspective on transnational organising beyond binaries. Such an approach recognises the key role of local alliances as well as the possibilities and limits arising from transnational organising initiatives to confront globalised capital.