The glucagon-like peptide 1 receptor agonist Exendin-4 induces tenogenesis in human mesenchymal stem cells

Abdulmalik, Sama; Ramos, Daisy M.; Rudraiah, Swetha; Banasavadi-Siddegowda, Yeshavanth; Kumbar, Sangamesh G.

doi:10.1016/j.diff.2021.05.001

Cited by 7 publications

(7 citation statements)

References 51 publications

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“…Previously, we investigated the efficacy of Ex-4 to cue hMSCs toward tenogenesis in vitro. The results demonstrated that Ex-4 promoted tenogenic differentiation of hMSCs [ 50 ]. To further our investigation, a rat tendon repair model was used to evaluate the performance of the scaffold in an in vivo environment, which helps with understanding the cellular and tissue healing level in a living organism [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

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Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

Abdulmalik

Gallo

Nip

et al. 2023

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

“…The samples were then stored at −80 °C until the end of the study. The RNA extraction was conducted following a previous protocol [ 50 ]. A 1 μg sample of RNA was reverse transcribed using an iScript cDNA synthesis kit and iTaq SYBR green kit was used for PCR using a BioRad CFX96 machine.…”

Section: Methodsmentioning

confidence: 99%

Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

Abdulmalik

Gallo

Nip

et al. 2023

Bioactive Materials

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“…To assess the cytotoxicity of 5BDBD and dye formulations, the metabolic activity of cultured fibroblasts was measured using an MTS assay. 82 The accumulation of nanocarriers was visualized using NR dye, and treatment efficacy was assessed by measuring infarct volume. 83 Tail vein injections of liposomal formulations were administered twice after 4-and 28-hours following stroke onset.…”

Section: Cytotoxicity and Cell Proliferationmentioning

confidence: 99%

Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy

Arul,

Alahmadi,

Turro

et al. 2023

Biomater. Sci.

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“…IGF-1 is highly expressed in the early stages of inflammation and promotes collagen production by tendon fibroblasts [ 160 ]. Muench et al .…”

Section: Biological Factors For Repairing Tendons and Ligamentsmentioning

confidence: 99%

Functional biomaterials for tendon/ligament repair and regeneration

Tang

Wang

Xiang

et al. 2022

Regenerative Biomaterials

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With an increase in life expectancy and the popularity of high-intensity exercise, the frequency of tendon and ligament injuries has also increased. Owing to the specificity of its tissue, the rapid restoration of injured tendons and ligaments is challenging for treatment. This review summarises the latest progress in cells, biomaterials, active molecules, and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of natural polymers, synthetic polymers, and composite materials has boosted the use of scaffolds. In addition, the development of electrospinning and hydrogel technology has diversified the production and treatment of materials. First, this paper briefly introduces the structure, function, and biological characteristics of tendons/ligaments. Then, it summarises the advantages and disadvantages of different materials, such as natural polymer scaffolds, synthetic polymer scaffolds, composite scaffolds, and ECM-derived biological scaffolds, in the application of tendon/ligament regeneration. We then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration engineering. Finally, we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.

show abstract

The glucagon-like peptide 1 receptor agonist Exendin-4 induces tenogenesis in human mesenchymal stem cells

Cited by 7 publications

References 51 publications

Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy

Functional biomaterials for tendon/ligament repair and regeneration

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