The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine

Effect of porcine glucagon‐like peptides‐2 on tight junction in GLP‐2R + IPEC‐J2 cell through the PI3k/Akt/mTOR/p70S6K signalling pathway

“…By contrast, Pedersen et al. () found that the expression of GLP‐2R with qRT‐PCR was confined to compartments containing enteric neurons, and receptor expression was absent in the epithelia. The explanation for these conflicting reports may be related to differences in the methods.…”

Glucagon‐like peptide‐2 mobilizes lipids from the intestine by a systemic nitric oxide‐independent mechanism

“…The precise pool(s) of intestinal lipid storage remain undefined, with possible candidate locales being intracellular cytoplasmic lipid droplets, the lamina propria under the epithelium, the lacteals, and the larger mesenteric lymph ducts . GLP‐2 receptors are not expressed on enterocytes where chylomicron synthesis and assembly occur. Instead, they are mostly identified on enteroendocrine neurons and subepithelial myofibroblasts, many of which are located in the subepithelial regions of the intestine, including the lamina propria.…”

“…post‐chylomicron assembly and secretion from the enterocyte) . Although GLP‐2 receptors are expressed abundantly in the gastrointestinal tract, they are identified on enteroendocrine neurons and subepithelial myofibroblasts, but not on enterocytes …”

The effect of glucagon‐like peptide‐1 and glucagon‐like peptide‐2 on microcirculation: A systematic review

“…However, there is an ongoing debate, regarding the precise localization of GLP‐2 receptors in the intestines. A recent study indicates that no expression in the epithelium exists, but rather in the enteric neurons and the nonepithelial cells, indicating a neuroendocrine effect . The GLP‐2‐mediated effect on the microcirculation may be due to subsequent expression of the vasodilatory transmitters, NOS and vasoactive intestinal peptide in enteric neurons .…”