The glucocorticosterone response to novelty as a psychological stressor

Pfister, H.

doi:10.1016/0031-9384(79)90154-9

Cited by 101 publications

(32 citation statements)

References 20 publications

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“…However, when rats received footshocks, plasma corticosterone levels increased, as expected, and repetition of the stressor stimulus caused a more pronounced response, indicating that animals had not adapted to the stressor. Many authors have shown that plasma corticosterone responses are reduced in rats following repeated presentation of noise (21,22), handling (23), novelty (24,25) or restraint (26), whereas with the use of relative intense stressors such as footshock (27), cold exposure (27), forced running (27,28) or a combina- (29), no such adaptation was detected. Our stressed rat model presented higher plasma corticosterone levels before the second and third footshock sessions compared to control rats, indicating that with repetition of the stressful stimulus some anticipation rather than adaptation to the stressor may occur.…”

Section: Discussionmentioning

confidence: 99%

Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats

Verago

Kassisse

Spadari-Bratfisch

2001

Braz J Med Biol Res

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Stress hormones can alter metabolic functions in adipose tissue and liver, as well as the sensitivity of rat white adipocytes and rat atrial responses to ß-adrenergic agonists. In this study, we examined the effects of three daily footshock stress sessions on the plasma corticosterone, glucose, glycerol and triacylglycerol levels of fed, conscious male rats, and on the plasma glucose, glycerol and triacylglycerol levels of the same rats following iv infusions of ß-adrenergic agonists (isoproterenol: 0.4 nmol kg -1 min -1 , noradrenaline: 5.0 µg kg -1 day -1 , and BRL 37344 ([±]-[4-(2-[(2-[3-chlorophenyl]-2-hydroxyethyl) amino]propyl)phenoxy]acetic acid), a selective ß 3 -adrenoceptor agonist: 0.4 nmol kg -1 min -1 ). Plasma corticosterone levels increased significantly after each stress session, while triacylglycerol levels increased after the first session and glucose increased after the second and third sessions. Glycerol levels were unaltered after stress. These results suggest that repeated footshock stress may induce a metabolic shift from triacylglycerol biosynthesis to glucose release by hepatic tissue, with glycerol serving as one of the substrates in both pathways. Stressed rats were more sensitive to infusion of noradrenaline plus prazosin and to infusion of isoproterenol, with elevated plasma glucose, glycerol and triacylglycerol levels. The higher sensitivity of stressed rats to isoproterenol and noradrenaline was probably related to the permissive effect of plasma corticosterone. Only BRL 37344 increased plasma glycerol levels in stressed rats, probably because ß 3 -adrenoceptors are not involved in hepatic triacylglycerol synthesis, thus allowing glycerol to accumulate in plasma.

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Section: Discussionmentioning

confidence: 99%

Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats

Verago

Kassisse

Spadari-Bratfisch

2001

Braz J Med Biol Res

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“…It has already been shown in rats that plasma catecholamine levels are not sensitive to such a stimulus (Mc C ARTY & K OPIN , 1978 ;N ATELSON et al, 1981) which is in contrast to the exquisite sensitivity of the pituitary-adrenal axis (P FISTER , 1979 (1972) for plasma 11-hydroxycorticosteroid levels. Sex differences in adrenocortical axis activity and reactivity are well documented in laboratory rats.…”

Section: A Animalsmentioning

confidence: 98%

Differences in adaptive abilities of three breeds of Chinese pigs. Behavioural and neuroendocrine studies

Mormède¹,

Dantzer²,

Bluthe³

et al. 1984

Genetics Selection Evolution

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“…Even relatively mild stressful events during pregnancy in rats can lead to release of ACTH and, thus, increased plasma levels of corticosterone (Ader & Plaut, 1968;Pfister, 1979;Pfister & Muir, 1989). Since corticosterone readily crosses the blood-placenta barrier (Zarrow, Philpott, & Denenberg, 1970), maternal corticosterone may influence the neuronal development of the fetus directly.…”

Section: Introductionmentioning

confidence: 98%

Prenatal stress effects on exploratory activity and stress‐induced analgesia in rats

Szuran¹,

Zimmerman²,

Pliška³

et al. 1991

Developmental Psychobiology

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Pregnant rats were exposed three times daily to immobilization stress during gestational Days 15-19. The behavior of their offspring was compared with the behavior of offspring from unstressed control mothers. Although the stress procedure decreased the weight gain of mothers during pregnancy, it slightly but significantly increased the weight of their offspring at birth and at weaning. On postnatal Day 10, prenatally stressed pups returned to their home cage more quickly than did prenatally unstressed control pups during a nest odor discrimination task, but no differences between groups in the number of correct responses were found. On postnatal Days 70-72, prenatally stressed offspring showed increased exploratory activity in a complex tunnel maze compared with control offspring. On postnatal Day 80, analgesia induced by stress (swimming for 3 min in cold water) was determined (tail flick latency). The degree of stress-induced analgesia was smaller in prenatally stressed rats than in control rats. These data suggest that the effects of prenatal stress on behavior are most clearly discernable when such animals are confronted with a novel or stressful situation.

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The glucocorticosterone response to novelty as a psychological stressor

Cited by 101 publications

References 20 publications

Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats

Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats

Differences in adaptive abilities of three breeds of Chinese pigs. Behavioural and neuroendocrine studies

Prenatal stress effects on exploratory activity and stress‐induced analgesia in rats

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