The Glucose Effect and the Relationship between Glucose Permease, Acid Phosphatase, and Glucose Resistance

Englesberg, Ellis; Watson, John; Hoffee, Patricia A.

doi:10.1101/sqb.1961.026.01.033

Cited by 47 publications

(22 citation statements)

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“…The explanation for this observation is that uncoupling of oxidative phosphorylation is known to increase the rate of formation of PEP (49). That PEP plays a pivotal role in the uptake process is also supported by the fact that under the conditions where azide stimulates methyl a-glucoside transport, the well known anaerobic glycolysis inhibitor, iodoacetate, markedly depresses the rate (48). Similar considerations apply to the results of experiments where the cells are supplied with rapidly metabolizable compounds during methyl a-glucoside uptake (43,50,51); these compounds are found to inhibit uptake.…”

Section: T R a N S P O R T P R O T E I N Ssupporting

confidence: 66%

“…At concentrations of azide and dinitrophenol that should uncouple oxidative phosphorylation, the transport rate of methyl a-glucoside is greatly stimulated, rather than inhibited (48). The explanation for this observation is that uncoupling of oxidative phosphorylation is known to increase the rate of formation of PEP (49).…”

Section: T R a N S P O R T P R O T E I N Smentioning

confidence: 99%

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The Transport of Carbohydrates by a Bacterial Phosphotransferase System

Roseman

1969

The Journal of General Physiology

304

129

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The components and properties of a phosphoenolpyruvate: glucose phosphotransferase system are reviewed, along with the evidence implicating this system in sugar transport across bacterial membranes. Some possible physiological implications of sugar transport mediated by the phosphotransferase system are also considered. This paper is concerned with a bacterial phosphotransferase system; its properties, and evidence indicating it to be responsible for sugar transport in bacterial cells will be briefly reviewed, and some speculations will be offered concerning the physiological implications of sugar transport via this system.The discovery of the phosphotransferase system resulted from our longstanding interest in the biosynthesis of carbohydrate containing macromolecules (1). The 9-carbon sugar acid, sialic acid, is a frequent component of these macromolecules, and enzymatic degradation of one of the sialic acids (N-acetylneuraminic acid) was found to give pyruvate and N-acetyl-Dmannosamine (2). Studies on the metabolism of the latter sugar led to the discovery of a specific kinase that catalyzes the reaction shown in Fig. 1 ; this kinase is widely distributed in animal tissues (3). Since certain bacterial cells synthesize polymers of N-acetylneuraminic acid, or can metabolize N-acetyl-D-mannosamine, extracts of these cells were examined for the kinase. The sugar was not phosphorylated by the reaction shown in Fig. 1, but it was phosphorylated when phosphoenolpyruvate (PEP) was substituted for ATP. The bacterial system, designated PEP:glycose phosphotransferase system, or simply phosphotransferase system, was found to catalyze the reaction shown in Fig. 2 (4, 5).

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Section: T R a N S P O R T P R O T E I N Ssupporting

confidence: 66%

Section: T R a N S P O R T P R O T E I N Smentioning

confidence: 99%

The Transport of Carbohydrates by a Bacterial Phosphotransferase System

Roseman

1969

The Journal of General Physiology

304

129

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“…It has been found that the presence of extracellular glucose represses the t:xpression of the citrate permeation systems of Snli~~onelln typlziinuriunz (3,4). Since Ihe R T medi~tm contains rather largc quantilies of glucose (278 mM), it was possible that tlie uptake of tartrate could be enhanced by lowering the extracellular glucose levels while keeping the ammonium ion at 36 mM.…”

Section: Resultsmentioning

confidence: 97%

“…Magasanik (9) has proposed that the citrate permease of Saltnonelln ryphinzurirnn is sensitive to catabolite repression, for it has been found that the bacterium would not take u~ citrate from g!ucose-containing media until the supply of glucose had been exhausted (4).…”

Section: I1mentioning

confidence: 99%

Factors influencing tartrate uptake by Penicillium charlesii

Klatt¹,

Gander²

1968

Can. J. Microbiol.

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The uptake of tartrate by P. clcnrlesii has been studied for cult~~res that were either aerated by shaking or were kept stationary. Stationary cultures were permeable to tartrate when high concentrations of NH4+ (above 36 mM) and glucose (278 mM) were present. Manganous ion (10-5 M ) was required for the uptake of tartrate by stationary cultures containing high concentrations of NH4+. Both stationary and shake cultures were able to remove tartrate from the medium when the glucose concentration was reduced below 278 mM; the process was then no longer dependent upon the presence of MnZ1-. The influence of changes in the concentrations of glucose and NH4+ was not related to the biochemical events of spore germination.

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“…It still retained, however, the ability of the wild type to use the TCA cycle intermediates (Englesberg et al, 1961). An earlier observation of a similar phenomenon was re ported by Utter and Keech (i960) with pyruvate carboxylase from avian liver.…”

Section: Anaplerotic Co^-fixationmentioning

confidence: 49%

Assimilation of carbon dioxide by enterococci

Lachica

Victor²

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The Glucose Effect and the Relationship between Glucose Permease, Acid Phosphatase, and Glucose Resistance

Cited by 47 publications

References 0 publications

The Transport of Carbohydrates by a Bacterial Phosphotransferase System

The Transport of Carbohydrates by a Bacterial Phosphotransferase System

Factors influencing tartrate uptake by Penicillium charlesii

Assimilation of carbon dioxide by enterococci

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