1993
DOI: 10.1016/s0021-9258(17)46741-x
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The glucose transporter GluT4 and secretory carrier membrane proteins (SCAMPs) colocalize in rat adipocytes and partially segregate during insulin stimulation.

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Cited by 112 publications
(16 citation statements)
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“…As noted above, GLUT4-enriched vesicles contain a muscleand fat-specific aminopeptidase, gp160 , and they also possess three antigenically related integral membrane proteins of unknown function, called SCAMPs/GTV3 for secretory component-associated membrane protein/glucose transporter vesicle triplet (Brand et al, 1991;Thoidis et al, 1993;Laurie et al, 1993). Fig.…”
Section: Resultsmentioning
confidence: 97%
“…As noted above, GLUT4-enriched vesicles contain a muscleand fat-specific aminopeptidase, gp160 , and they also possess three antigenically related integral membrane proteins of unknown function, called SCAMPs/GTV3 for secretory component-associated membrane protein/glucose transporter vesicle triplet (Brand et al, 1991;Thoidis et al, 1993;Laurie et al, 1993). Fig.…”
Section: Resultsmentioning
confidence: 97%
“…Probably the best correlation was observed between the staining of pantophysin and SCAMPs, which are integral membrane proteins of secretory and cell surface recycling vesicles (Fig. 7, d and d'; see references 7,8,38). Furthermore, cellubrevin, a cellular homologue of the synaptic vesicle protein synaptobrevin (47), showed significant colocalization with pantophysin in A431 cells as well (Fig.…”
Section: Pantophysin Colocalization With Cytoplasmic Vesicle Markersmentioning
confidence: 83%
“…For example, isoforms of the vSNARE synaptobrevin have been shown to colocalize with transferrincontaining recycling vesicles in fibroblasts (24, 47), with vesicles in the ER/Golgi region of skeletal muscle (58, 71), with zymogen granules of exocrine cells and dense core vesicles of J3 cells in pancreas (9, 59), with glucose transporter--containing vesicles in adipocytes(10), or water channels in the collecting ducts of kidney(22). Conversely, SCAMPs are not only constituents of secretory and endocytotic vesicles in nonneuroendocrine cells but also of synaptic vesicles(7,8,38). Expression of the individual family members is not mutually exclusive (see for exampleFig.…”
mentioning
confidence: 99%
“…8) roughly corresponding to a molecular mass of 160 kD, which is in excellent agreement with the original observation by . We saw no overlap between the sedimentation patterns of detergent-solubilized caveolin and GLUT4, or other known proteins of GLUT4-contalning vesicles such as GTV3/SCAMPs (Thoidis et al, 1993;Laurie et al, 1993) and small GTP-binding proteins (Cormont et al, 1991). When solubilized in detergent, these vesicular components sediment as monomers in the zone corresponding to their predicted molecular mass (data not shown).…”
Section: R E S U L T Smentioning
confidence: 86%