The GnRH Increase Following Progesterone Withdrawal is Associated with an Increased Glutamatergic Tone in the Preoptic Area of the Ovariectomized Ewe

Caraty, Alain; Skinner, Donal C.; Huyghe, Bruno; Bertault, Tatiana; Picard, Sophie; Delaleu, Bernadette; Malpaux, Benoît; Thiéry, Jean Claude

doi:10.1111/j.1749-6632.1998.tb10797.x

Cited by 3 publications

(1 citation statement)

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“…The generation of episodic pulses of GC secretion was thought to be mediated by a pulse generator in the hypothalamus. Indeed, Mershon et al, (Mershon et al, 1992) did detect an episodic release of CRH from macaque hypothalamic explants while rapid changes in CRH levels were detected both from the median eminence of rat (Ixart et al, 1991) and portal blood from the sheep (Caraty et al, 1998). There was however, no clear relationship between the rapid CRH pulses as they were detected in these systems and the much slower hourly ultradian rhythm detected for CORT.…”

Section: Ontogeny Of Rhythmic Hpa Axis Activitymentioning

confidence: 96%

Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis

Fitzsimons

Herbert

Schouten

et al. 2016

Frontiers in Neuroendocrinology

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Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learning and memory. However, the mechanisms by which stress, and particularly glucocorticoids, inhibit neural stem/progenitor cell proliferation remain unclear and under debate. Here we review the literature on the topic and discuss the evidence for direct and indirect effects of glucocorticoids on neural stem/progenitor cell proliferation and adult neurogenesis. Further, we discuss the hypothesis that glucocorticoid rhythmicity and oscillations originating from the activity of the hypothalamus-pituitary-adrenal axis, may be crucial for the regulation of neural stem/progenitor cells in the hippocampus, as well as the implications of this hypothesis for pathophysiological conditions in which glucocorticoid oscillations are affected.

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Section: Ontogeny Of Rhythmic Hpa Axis Activitymentioning

confidence: 96%