The Gonadotrophin Resistant Ovary Syndrome: A Curable Disease?

Evers, Johannes L.H.; Rolland, Rosalind M.

doi:10.1111/j.1365-2265.1981.tb00370.x

Cited by 14 publications

(4 citation statements)

References 10 publications

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“…[9] A patient experienced first real menstrual bleeding for 7 years, just after she stopped receiving replacing hormone therapy, which caused gonadotropin rebound phenomenon. [12] Furthermore, a patient got effective ovarian stimulation after FSH receptors upregulation due to endogenous gonadotropins down regulation by using of cyclic hormone supplementation with oral estradiol with levonogestril. [6] Another patient got spontaneously pregnant twice while receiving replacing hormone therapy, which she started 6 years ago, with a twin delivered by one of Figure 6: shows the thickness of the endometrium after application of treatment.…”

Section: Discussionmentioning

confidence: 99%

Hydrocortisone as a Potential Treatment of Savage Ovary Syndrome: A Rare Case from Syria

Adwan¹

2020

AMDHS

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A 32-year old woman with a secondary amenorrhea for 5 years presented to my clinic (April 2019), previously had been treated as a premature ovarian failure patient and put on HRT. With further investigation, FSH Levels were high at the menopausal range, whereas the AMH levels and antral follicles count were within normal ranges and found to be age-compatible, These findings, as well as the failure of ovaries to respond to exogenous gonadotropins, helped to set the diagnosis of Savage Ovary Syndrome, which is also known as Insensitive Ovary Syndrome (IOS). Written informed consent was obtained from the patient for publication of this case report and accompanying images" Patient was convinced to be treated empirically with a high dose of Hydrocortisone and the result was the patient well responded as a normal spontaneous menstruation happened. The analysis of FSH and estradiol induces normal values and the return of the functional activity of the ovary to the formation of multiple ovarian bilateral follicle and give an echo feature similar to the ovarian hyper stimulatory syndrome with an increase the thickness of the endometrium. This case shows the importance of further studying patients with secondary amenorrhea and high levels of gonadotropins and not to treat them all as premature ovary insufficiency patients, just like our patient was firstly treated for a long time. Furthermore, the case highlights the potential benefit of the treatment of Savage Ovary Syndrome patients with Hydrocortisone.

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Section: Discussionmentioning

confidence: 99%

Hydrocortisone as a Potential Treatment of Savage Ovary Syndrome: A Rare Case from Syria

Adwan¹

2020

AMDHS

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“…Other cases have been reported without sufficient data to permit inclusion in this review. 16,45,[50][51][52][53] Even with these cases included, the literature contains fewer than 30 patients who have been adequately investigated and who can confidently be diagnosed as having the gonadotropin resistant ovary syndrome.…”

Section: Incidence Of the Gonadotropin Resistant Ovary Syndromementioning

confidence: 99%

The Gonadotropin Resistant Ovary Syndrome

Maxson¹,

Wentz²

1983

Semin Reprod Med

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“…[1][2][3][4] Due to the low incidence of ROS, few large sample studies have been conducted involving successful cases. Pregnancies resulting from the patient's own oocytes have mainly been achieved through hormone replacement therapy (HRT) [5][6][7][8][9][10][11][12] or in vitro maturation (IVM), [13][14][15][16][17][18][19] and a handful of conventional in vitro fertilization (c-IVF) after controlled ovarian stimulation (COS). [17,[20][21][22] Therefore, ROS patients who are unable to produce mature oocytes may have to resort to donor oocytes.…”

Section: Introductionmentioning

confidence: 99%

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF

Zhao,

Zheng,

et al. 2024

Medicine

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Introduction: Resistant ovary syndrome (ROS) represents a rare reproductive endocrine disorder that is predominantly associated with infertility, characterized by heightened endogenous gonadotropin levels in the presence of a normal ovarian reserve. Patients with ROS typically exhibit a poor response to exogenous gonadotropins during controlled ovarian stimulation (COS). Due to the absence of a universally accepted effective COS protocol, this study aims to contribute to the existing body of literature by detailing 2 successful pregnancies achieved through conventional in vitro fertilization (c-IVF) in patients with ROS, and through retrospective analysis, seeks to elucidate the factors contributing to the successful ovarian stimulation in these cases, with the ultimate goal of establishing clinical guidelines for ROS management. Patient Concerns: The central challenge addressed in this study pertains to the effective induction of oocyte maturation during c-IVF COS in ROS patients. Diagnosis: The study focuses on 2 infertile women diagnosed with ROS who sought to conceive via c-IVF. Interventions: The patients were subjected to a COS protocol involving pituitary downregulation followed by ovarian stimulation using recombinant follicle-stimulating hormone (r-FSH) and human menopausal gonadotropin (HMG), preceded by 3 cycles of hormone replacement therapy (HRT) pretreatment. Outcomes: The proposed protocol elicited a favorable ovarian response, culminating in the retrieval of numerous mature oocytes and the development of multiple viable embryos via c-IVF, ultimately leading to successful live births post-embryo transfer. Conclusions: Our study suggests that the outlined COS protocol may serve as a viable treatment option for ROS patients aspiring to conceive through c-IVF, thereby potentially expanding the therapeutic repertoire for this challenging condition.

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The Gonadotrophin Resistant Ovary Syndrome: A Curable Disease?

Cited by 14 publications

References 10 publications

Hydrocortisone as a Potential Treatment of Savage Ovary Syndrome: A Rare Case from Syria

Hydrocortisone as a Potential Treatment of Savage Ovary Syndrome: A Rare Case from Syria

The Gonadotropin Resistant Ovary Syndrome

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF

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