The Good, the Bad, and the Hoax: When Publication Instantaneously Impacts Treatment Strategies for COVID-19

Danion, François; Ruch, Yvon; Fourtage, Marion; Kaeuffer, Charlotte; Greigert, Valentin; Lefèbvre, Nicolas; Müller, J.; Nai, Thierry; Hansmann, Yves

doi:10.1128/aac.01127-20

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…In late May 2020, after clear evidence of likely prolongation of the QTc interval, and of unfavourable data on the use of HCQ, AIFA suspended the approval of HCQ [ 11 ]. A progressive decrease in HCQ DDDs was reported in our centre, as reported in other health care settings, such as France [ 1 ]. Finally, a study from the United States described a HQC drug shortage for patients affected by rheumatologic diseases between March and May 2020 [ 12 ].…”

Section: Discussionsupporting

confidence: 80%

“…Management of inpatients was based on discordant or contradictory clinical protocols developed by the World Health Organization (WHO), national and international public health agencies, and infectious disease societies with very scarce medical evidence. Physicians involved in COVID-19 clinical management were confused and unsettled, waiting for information on therapeutic progresses and ready to eventually modify their standard of care in case of data from cases series, cohort studies, or clinical trials [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Drug Policies Skyline during COVID-19 Pandemic

Vita

Forliano

Luca

et al. 2021

JCM

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The COVID-19 pandemic has produced an extraordinary care setting where physicians played, and continue to play, a critical role in containing viral spread and treating affected patients. Frontline workers have been receiving day-to-day new information about therapeutic advances. The purpose of the study is to analyse COVID-19 drug consumption trends in both acute and intensive care settings comparing Defined Daily Doses and the release of scientific clinical data from January to December 2020.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Drug Policies Skyline during COVID-19 Pandemic

Vita

Forliano

Luca

et al. 2021

JCM

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“…Furthermore, misinformation was inevitable when trial and error was part of the emergency medical response. This was apparent in experimenting with hydroxychloroquine and lopinavir–ritonavir as a treatment strategy ( Danion et al, 2020 ). U.S. politicians used these experiments for political gain to abate fears ( Alvarez & Barney, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Validation of the COVID-19 Disbelief Scale: Conditional indirect effects of religiosity and COVID-19 fear on intent to vaccinate

2021

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The COVID-19 pandemic uprooted economies, infected millions, and altered behaviors. Yet, the invisible nature of the disease, paralleled symptoms to the common flu, and misinformation generated COVID-19 disbelief. Many believed COVID-19 was a hoax. Many believed case numbers were fabricated. Others claimed it was a ruse for sociopolitical reasons. The construction of the 8-item COVID-19 Disbelief Scale (CDS) measures the false belief COVID-19 was not real and life-threatening. The CDS demonstrated discriminant validity and robust reliability across two studies. Predictive analysis evinced COVID-19 disbelievers feared COVID-19 less and had lower intent to get vaccinated. In the U.S., certain religious organizations spread misinformation. Religiosity associated with greater COVID-19 disbelief. Among disbelievers, conditional indirect effects of religiosity associated with greater COVID-19 fear and higher intent to get vaccinated. The moderated mediation model validated utility of the CDS as a concise instrument to study variable relationships.

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A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2

et al. 2020

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Objectives SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was to investigate the effects of a 1% hydrogen peroxide mouthrinse on reducing the intraoral SARS-CoV-2 load. Methods Twelve out of 98 initially screened hospitalized SARS-CoV-2-positive patients were included in this study. Intraoral viral load was determined by RT-PCR at baseline, whereupon patients had to gargle mouth and throat with 20 mL of 1% hydrogen peroxide for 30 s. After 30 min, a second examination of intraoral viral load was performed by RT-PCR. Furthermore, virus culture was performed for specimens exhibiting viral load of at least 103 RNA copies/mL at baseline. Results Ten out of the 12 initially included SARS-CoV-2-positive patients completed the study. The hydrogen peroxide mouthrinse led to no significant reduction of intraoral viral load. Replicating virus could only be determined from one baseline specimen. Conclusion A 1% hydrogen peroxide mouthrinse does not reduce the intraoral viral load in SARS-CoV-2-positive subjects. However, virus culture did not yield any indication on the effects of the mouthrinse on the infectivity of the detected RNA copies. Clinical relevance The recommendation of a preprocedural mouthrinse with hydrogen peroxide before intraoral procedures is questionable and thus should not be supported any longer, but strict infection prevention regimens are of paramount importance. Trial registration German Clinical Trials Register (ref. DRKS00022484)

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The Good, the Bad, and the Hoax: When Publication Instantaneously Impacts Treatment Strategies for COVID-19

Abstract: The COVID-19 pandemic is an unprecedented situation with physicians awaiting information on therapeutic advances to an extent hardly ever seen in medical history.…

Cited by 4 publications

References 8 publications

Drug Policies Skyline during COVID-19 Pandemic

Drug Policies Skyline during COVID-19 Pandemic

Validation of the COVID-19 Disbelief Scale: Conditional indirect effects of religiosity and COVID-19 fear on intent to vaccinate

A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2

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