The GPR17 Receptor—A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis

Dziedzic, Angela; Miller, Elżbieta; Saluk‐Bijak, Joanna; Bijak, Michał

doi:10.3390/ijms21051852

Cited by 24 publications

(19 citation statements)

References 118 publications

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“…In another study the conformational analysis of the immunodominant epitope of acetylated myelin basic protein residues 1-11 (Ac-MBP1-11) and its ALPs, mutated at position 4 to an alanine (Ac-MBP1-11(4A)) or a tyrosine residue (Ac-MBP1-11(4Y)), was achieved. The amino acids constituting the MBP [1][2][3][4][5][6][7][8][9][10][11] are Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly (Ac-MBP1-11). The Ac-MBP1-11(4A) analogue inhibited EAE symptoms induced by encephalitogenic Ac-MBP1-11 epitope when co-injected in (PL/J × SJL)F1 mice.…”

Section: Resultsmentioning

confidence: 99%

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A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis

et al. 2020

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Multiple sclerosis (MS) is a serious central nervous system (CNS) disease responsible for disability problems and deterioration of the quality of life. Several approaches have been applied to medications entering the market to treat this disease. However, no effective therapy currently exists, and the available drugs simply ameliorate the destructive disability effects of the disease. In this review article, we report on the efforts that have been conducted towards establishing the conformational properties of wild-type myelin basic protein (MBP), myelin proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG) epitopes or altered peptide ligands (ALPs). These efforts have led to the aim of discovering some non-peptide mimetics possessing considerable activity against the disease. These efforts have contributed also to unveiling the molecular basis of the molecular interactions implicated in the trimolecular complex, T-cell receptor (TCR)–peptide–major histocompatibility complex (MHC) or human leucocyte antigen (HLA).

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Section: Resultsmentioning

confidence: 99%

“…It affects more females than males between the ages of 20 and 40 [2]. MS-related disability significantly affects the quality of life (e.g., restraints on daily life activities) [3]. As the number of patients continuously increases, negative effects on social and economic aspects have been observed [4,5].…”

Section: Introductionmentioning

confidence: 99%

A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis

et al. 2020

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“…At present, it was found that GPR17 was mainly con ned to oligodendrocyte cell lines and was very important for myelin formation in oligodendrocytes [99] . It was considered to be closely related to multiple sclerosis [100] . GPR17 agonists can inhibit glioma cell proliferation [101] .…”

Section: Discussionmentioning

confidence: 99%

Understand the role of exosomal miRNA in the development of breast cancer in patients with chronic HBV infection

Xie¹,

Chen²,

Lin³

et al. 2021

Preprint

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Background: Female chronic hepatitis B patients has shown a higher incidence of breast cancer with poorer prognosis, compared to the non-infected female patients. A significant difference in miRNAs expression in serum exosomes has been identified between female patients with chronic HBV infection and non-infected female. Whether this difference could contribute to the differential incidence and development of breast cancer in these female patients has not been fully understood.Methods: Information of exosomal expression of miRNAs (expression profiles of GSE33857) were acquired from the Gene Expression Omnibus (GEO) database. Targeted genes of this miRNAs and the differentially expressed genes of breast cancer in GEPIA V2.0 database was used to obtain the differentially expressed genes (DEGs). Four analytic methods were performed, including functional annotation, protein-protein interaction (PPI) network and module construction, the clinical pathologic parameters analysis, alongsides prognosis analysis.Results: In the serum exsomes, expression of miR-1237-3p and miR-363-3p were down-regulated whilst expression of miR-100-5p, miR-125b-5p, miR-1260a, miR-1287-5p, miR-148a-3p, miR-885-5p and miR-99a-5p were up-regulated in female chronic hepatitis B (CHB) patients. 228 up-regulated genes and 641 down-regulated genes were selected as DEGs. The DEGs involved in several biological processes ranging from cellular response to hormone stimulus. According to the main enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was the pathways in cancer. Our analysis revealed that among the hub genes, CXCL11 was up-regulated and CXCL12, GNG2, LPAR1, GPR17, CXCL1, ADCY5, ADCY3, CX3CL1, S1PR1 were down-regulated. These genes expression levels were verified in UALCAN, Oncomine and HPA database. High expression level of CXCL11 and low expression levels of CXCL12, LPAR1, ADCY3 and CX3CL1 were positively correlated with some clinical pathological parameters that predicted worse prognosis. Kaplan-Meier (K-M) plotter analysis revealed that these genes that showed a low expression level were positively correlated with poor prognosis of breast cancer, and the high expression genes were negatively correlated with poor prognosis of breast cancer.Conclusion: This bioinformatics analysis study explored the mechanisms of chronic HBV related occurrence and development of breast cancer by changing the expression of miRNAs of serum exosomes. It provided novel directions and therapeutic strategy for chronic HBV infection associated occurrence and development of breast cancer in female patients.

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“…Another family of GPCRs that has received increasing attention is the GPR17 receptors, which act as sensors of local damage to the myelin sheath. Modification of GPR17 activity promotes oligodendroglial maturation in vitro and in animal models (Merten et al, 2018 ; Dziedzic et al, 2020 ; Parravicini et al, 2020 ). Finally, the protective effects of pregnancy on MS relapse have led to the extensive focus on the estrogen receptor (ER) and its ligands as a means for promoting remyelination (Xiao et al, 2012 ; Moore et al, 2014 ; Najm et al, 2015 ; Itoh et al, 2017 ).…”

Section: Translational Approaches In Animal Modelsmentioning

confidence: 99%

Strategies for Oligodendrocyte and Myelin Repair in Traumatic CNS Injury

Huntemer-Silveira

Patil

Brickner

et al. 2021

Front. Cell. Neurosci.

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A major consequence of traumatic brain and spinal cord injury is the loss of the myelin sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system. In the central nervous system (CNS), myelin is produced and maintained by oligodendrocytes. Damage to the CNS may result in oligodendrocyte cell death and subsequent loss of myelin, which can have serious consequences for functional recovery. Demyelination impairs neuronal function by decelerating signal transmission along the axon and has been implicated in many neurodegenerative diseases. After a traumatic injury, mechanisms of endogenous remyelination in the CNS are limited and often fail, for reasons that remain poorly understood. One area of research focuses on enhancing this endogenous response. Existing techniques include the use of small molecules, RNA interference (RNAi), and monoclonal antibodies that target specific signaling components of myelination for recovery. Cell-based replacement strategies geared towards replenishing oligodendrocytes and their progenitors have been utilized by several groups in the last decade as well. In this review article, we discuss the effects of traumatic injury on oligodendrocytes in the CNS, the lack of endogenous remyelination, translational studies in rodent models promoting remyelination, and finally human clinical studies on remyelination in the CNS after injury.

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The GPR17 Receptor—A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis

Cited by 24 publications

References 118 publications

A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis

A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis

Understand the role of exosomal miRNA in the development of breast cancer in patients with chronic HBV infection

Strategies for Oligodendrocyte and Myelin Repair in Traumatic CNS Injury

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