The grading of lymphovascular space invasion in endometrial carcinoma

Hachisuga, Toru; Kaku, Tsunehisa; Fukuda, Kouichi; Eguchi, Fuyuki; Emoto, Makoto; Kamura, Toshiharu; Iwasaka, Tsuyoshi; Kawarabayashi, Tatsuhiko; Sugimori, Hajime; Mori, Mitsuru

doi:10.1002/(sici)1097-0142(19991115)86:10<2090::aid-cncr29>3.0.co;2-7

Cited by 68 publications

(52 citation statements)

References 24 publications

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“…This is reflected by the varying percentages of LVSI reported for different series of patients with EC, and by the fact that a study comparing LVSI diagnosed by frozen section with that diagnosed by permanent section shows a relatively low agreement (68.3%) [10][11][12][13]. Given the present results and the difficulties in diagnosing LVSI intraoperatively, it does not seem unreasonable to incorporate tumor diameter as a surrogate of LVSI at the time of surgery in order to triage patients for a full surgical staging.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, however, only 1 study has reported on the accuracy of identifying LVSI by frozen section analysis [10]. LVSI diagnosis by permanent section analysis shows great variability because of technical issues [11][12][13]. It is reasonable to consider that this variability might be amplified in frozen section analysis when time constraints and sampling errors are taken into consideration.…”

Section: Introductionmentioning

confidence: 99%

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Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer

Laufer

Scasso

Papadia

et al. 2013

International Journal of Gynecology & Obstetrics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer

Laufer

Scasso

Papadia

et al. 2013

International Journal of Gynecology & Obstetrics

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“…Limited but emerging evidence suggests that extent of LVSI predicts for risk of lymph node metastasis in endometrial cancers with endometrioid or other favorable histologies (9,16,17). In a pooled analysis of the PORTEC-1 and 2 trials, Bosse et al determined that a 3-tiered quantification system for LVSI (none, focal, substantial) was most predictive for risk of distant metastases (18).…”

Section: Introductionmentioning

confidence: 99%

Extent of lymphovascular space invasion may predict lymph node metastasis in uterine serous carcinoma

Qian

Pollom

Nwachukwu

et al. 2017

Gynecologic Oncology

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Objectives Emerging evidence suggests that extent of lymphovascular space invasion (LVSI) predicts for risk of lymph node metastasis in endometrioid uterine cancers. However, this correlation remains unknown in the setting of uterine serous carcinoma (USC). We sought to examine the association between extent of LVSI and other histopathologic characteristics with risk of nodal metastasis for women with USC. Materials/Methods Pathological data from all cases of uterine serous carcinoma between July 1998 to July 2015 at our institution were reviewed. Descriptive, univariate, and multivariate logistic regression analysis of selected pathologic features were performed. Results 88 patients with USC underwent total abdominal or laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and selective lymphadenectomy. Surgical staging revealed the following FIGO stage distributions: I (41%), II (8%), III (32%), IV (19%). LVSI was present in 44 (50%) patients. 36 patients (41%) had LN metastases with median number of total nodes removed of 17 (range, 1–49). On univariate analysis, depth of myometrial invasion, LVSI, tumor size, and cervical stromal involvement were significantly associated with nodal involvement. In a multivariate model, LVSI (OR 6.25, 95% CI 2.2–18.0, p < 0.01) and cervical stromal involvement (OR 3.33, 95% CI 1.10–10.0, p = 0.03) were the only factors that remained significant. Among patients with LVSI-positive disease, extensive LVSI was associated with increased risk of nodal involvement compared to focal LVSI (90% vs 29%, p = 0.04). Conclusions Presence and extent of LVSI, and cervical stromal invasion are important predictors for lymph node metastasis in uterine serous carcinoma.

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“…Tumours with more than 10 mitoses per high-power fi elds are designated high-grade and those with less than 10 are considered low-grade [15,21]. The negative prognostic infl uence of a high mitotic count has been revealed in previous studies [2,13,22,23].…”

Section: Discussionmentioning

confidence: 99%