The “Great Imitator” Presents with Abnormal Liver Enzymes

Suzuki, Ms Iv; Orfanidis, Nicholas; Moleski, Stephanie; Katz, Leo C.; Kastenberg, David

doi:10.29046/tmf.011.1.015

Cited by 5 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Syphilis is a systemic human disease caused by the spirochaete T. pallidum , subspecies pallidum 1–4…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, syphilis is re-emerging as a global public health problem. In Europe, the number of syphilis has been consistently going up since 2010, mostly affecting men who have sex with men and heterosexual adults, aged 15–49 years, living in urban areas 2 5. Factors that drive the re-emergence and spread of syphilis include high-risk sexual activity, migration and travel 5…”

Section: Discussionmentioning

confidence: 99%

“…Syphilis develops in stages with different characteristic signs and symptoms. Primary syphilis is characterised by the presence of a painless, usually solitary, indurated ulcerative lesion, which appears 2–6 weeks after infection and is called chancre 2. Secondary syphilis results from a hematogenous and lymphatic dissemination of the infection and is often characterised by a generalised maculopapular rash, a lymphadenopathy, fever and malaise 6.…”

Section: Discussionmentioning

confidence: 99%

“…Secondary syphilis results from a hematogenous and lymphatic dissemination of the infection and is often characterised by a generalised maculopapular rash, a lymphadenopathy, fever and malaise 6. Further, but less frequent, manifestations are meningitis, iritis, hepatitis and a nephrotic syndrome 1–3 6…”

Section: Discussionmentioning

confidence: 99%

“…Characteristic manifestations of late syphilis, which occurs after a latent stage and mostly several years after the initial infection include neurosyphilis, cardiovascular syphilis and gummatous syphilis 2…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Cholestatic hepatitis with concomitant nephrotic syndrome due to late syphilis in an immunocompetent 32-year-old man

et al. 2020

View full text Add to dashboard Cite

A 32-year-old man was referred to our clinic for evaluation of abnormal liver function tests and concurrent proteinuria. Physical examination revealed a maculopapular rash, involving the trunk and palms, and multiple ‘moth-eaten’ patches of alopecia. After a prolonged diagnostic work-up a hepatitis with concomitant nephrotic syndrome due to secondary syphilis was diagnosed. Treatment with benzylpenicillin led to complete clinical recovery. Syphilis is a re-emerging infectious disease with heterogeneous clinical presentation that should be considered in the differential diagnosis of inexplicable simultaneous liver and kidney dysfunction in patients with high-risk sexual behaviour.Syphilis is a re-emerging infectious disease with heterogeneous clinical presentation that should be considered in the differential diagnosis of inexplicable simultaneous liver and kidney dysfunction in patients with high-risk sexual behaviour.

show abstract

“…Syphilis is a systemic human disease caused by the spirochaete T. pallidum , subspecies pallidum 1–4…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cholestatic hepatitis with concomitant nephrotic syndrome due to late syphilis in an immunocompetent 32-year-old man

et al. 2020

View full text Add to dashboard Cite

show abstract

Spirochetes in the Liver: An Unusual Presentation of a Common STI

Narang

Al-Jashaami

Patel

2019

Case Reports in Medicine

View full text Add to dashboard Cite

It is estimated that 10% of patients with secondary syphilis have liver enzyme elevations, but clinical hepatitis is rare. However, in HIV-positive patients, syphilitic hepatitis may be much more common. We report a case of a 67-year-old male who developed progressively elevated liver enzymes, followed by development of neurological symptoms and then rash. Though the timeline of his symptom development was unusual, his constellation of symptoms prompted an RPR and FTA-ABS which returned reactive. He was additionally found to be HIV positive with a CD4 count of 946. He was treated with IV Penicillin, and his hepatitis improved thereafter.

show abstract

A Systematic Literature Review of Syphilitic Hepatitis in Adults

Huang¹,

Lin²,

Wan³

et al. 2018

Journal of Clinical and Translational Hepatology

View full text Add to dashboard Cite

Syphilitic hepatitis in adults is not frequently found in the population and is easily misdiagnosed. The incidence of viral hepatitis is increasing year by year, concomitantly increasing the importance of obtaining a systematic understanding of the clinical features and treatment strategies for this disease. There is, however, a lack of published definitive data regarding the clinical characteristics, diagnosis and standard treatment options for this disease. Searches were made using the MEDLINE database of PubMed and OVID for syphilitic hepatitis publications from 1951 to 2017 in an attempt to analyze and summarize the clinical characteristics.

show abstract

The “Great Imitator” Presents with Abnormal Liver Enzymes

Cited by 5 publications

References 18 publications

Cholestatic hepatitis with concomitant nephrotic syndrome due to late syphilis in an immunocompetent 32-year-old man

Cholestatic hepatitis with concomitant nephrotic syndrome due to late syphilis in an immunocompetent 32-year-old man

Spirochetes in the Liver: An Unusual Presentation of a Common STI

A Systematic Literature Review of Syphilitic Hepatitis in Adults

Contact Info

Product

Resources

About