Hyperspectral imaging systems frequently rely on spectral rather than spatial resolving power for identifying objects within a scene. A hyperspectral imaging system’s response to point targets under flight conditions provides a novel technique for extracting system-level radiometric performance that is comparable to spatially unresolved objects.The system-level analysis not only provides a method for verifying radiometric calibration during flight but also allows for the exploration of the impacts on small target radiometry, post orthorectification. Standard Lambertian panels do not provide similar insight due to the insensitivity of orthorectification over a uniform area. In this paper, we utilize a fixed mounted hyperspectral imaging system (radiometrically calibrated) to assess eight individual point targets over 18 drone flight overpasses. Of the 144 total observations, only 18.1% or 26 instances are estimated to be within the uncertainty of the predicted entrance aperture-reaching radiance signal. For completeness, the repeatability of Lambertian and point targets are compared over the 18 overpasses, where the effects of orthorectification drastically impact the radiometric estimate of point targets. The unique characteristic that point targets offer, being both a known spatial and radiometric source, is that they are the only field-deployable method for understanding the small target radiometric performance of drone-based hyperspectral imaging systems.