The Growing Impact of Cardiovascular Oncology: Epidemiology and Pathophysiology

Tufano, Antonella; Coppola, Antonio; Galderisi, Maurizio

doi:10.1055/s-0041-1729885

Cited by 7 publications

(2 citation statements)

References 71 publications

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“…Cancer and cardiovascular diseases are common comorbidities [ 1 ]. Chemotherapeutic agents, as well as radiation therapy used for cancer treatment, can cause cardiovascular toxicities [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

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Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment. There are many mechanisms of radiation treatment exposure to toxicities. Our aim was to summarize the literature about known mechanisms of radiation-induced cardiac toxicities. We performed a systematic review of the literature on the PubMed database until October 2022 about cardiovascular toxicities and radiation therapy exposure. Only systematic reviews, meta-analyses, and reviews were selected. Out of 1429 publications screened, 43 papers met inclusion criteria and were selected for the umbrella review process. Microvascular and macrovascular complications could lead to adverse cardiac effects. Many radiotherapy-associated risk factors were responsible, such as the site of radiation treatment, beam proximity to heart tissues, total dosage, the number of radiotherapy sessions, adjuvant chemotherapeutic agents used, and patient traditional cardiovascular risk factors, patient age, and gender. Moreover, important dosage cutoff values could increase the incidence of cardiac toxicities. Finally, the time from radiation exposure to cardiac side effects was assessed. Our report highlighted mechanisms, radiation dosage values, and the timeline of cardiovascular toxicities after radiation therapy. All of the above may be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.

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Section: Introductionmentioning

confidence: 99%

Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review

Siaravas

Katsouras

Sioka

2023

IJMS

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“…The characteristics of cancer itself, treatment modalities, changes in homeostasis, and lifestyle may lead to cancer comorbidity with CVD. The cardiovascular (CV) risk in the patients’ background can be significantly increased because of the progress of cancer, especially through anticancer treatment [ 4 ]. In early-stage breast cancer, CVD is even the leading cause of death in elder women (> 66 years) with more than 5 years of survival time, followed by cancer itself [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Cardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism

et al. 2023

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Purpose of Review The article aims to investigate the complex relationship between cancer and cardiovascular disease (CVD), with a focus on the effects of cancer treatment on cardiac health. Recent Findings Advances in cancer treatment have improved long-term survival rates, but CVD has emerged as a leading cause of morbidity and mortality in cancer patients. The interplay between cancer itself, treatment methods, homeostatic changes, and lifestyle modifications contributes to this comorbidity. Recent research in the field of cardio-oncology has revealed common genetic mutations, risk factors, and metabolic features associated with the co-occurrence of cancer and CVD. Summary This article provides a comprehensive review of the latest research in cardio-oncology, including common genetic mutations, risk factors, and metabolic features, and explores the interactions between cancer treatment and CVD drugs, proposing novel approaches for the management of cancer and CVD.

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