This study aims to determine the effect of the use of coffee grounds and sawdust Tectona grandis L. F as planting media on the cultivation of oyster mushrooms Pleurotus sp. This research was conducted in December 2021 - March 2022. This study used a completely randomized design (CRD) method consisting of 1 factorial. This study used 5 treatments with 3 replications, so a total of 15 baglogs were used. The data obtained were analyzed statistically using the F test and further tested with the 5% Least Significant Difference (LSD). The results showed that the addition of several doses of coffee grounds had a significant effect on fruit body growth time, fruit body fresh weight, fruit body dry weight, and fruit cap diameter. The fastest growing time of oyster mushroom mycelium was at P0 (sawdust Tectona grandis 2 kg + control) an average of 4.67 days, the fastest fruit body formation speed was P0 (sawdust Tectona grandis 2 kg + control) with an average of 15.67 days, fresh fruit weight the fastest with an average of 106.33 g, the dry weight of the fruit body of the heaviest oyster mushroom with an average of 33 g, and the diameter of the largest fruit hood with an average of 30.3 cm, meanwhile for the P3 treatment (sawdust Tectona grandis 0.5 kg + 1.5 kg coffee grounds) and P4 (coffee grounds 2 kg + control) were not suitable for the growth of oyster mushrooms.