The growth and development of living organisms from the thermodynamic point of view

Зотин, А. А.; Pokrovskii, Vladimir N.

doi:10.1016/j.physa.2018.08.094

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…However, our analysis reflects the potentiality to disease onsets by elF4E and mTOR deregulations. As the internal variables of a living organism are trying to keep its internal state unchangeable (homeostasis), and the reactions between analogue caps and elF4E are thermodynamically not favorable [1][2][3][4], this has to be analyzed by further superior physical chemistry, biochemistry and explicit toxicity evaluation research. Particularly during sensitive circumstances, as during deregulation of fine balance of cellular homeostasis (conditions of elF4E and mTORC1 deregulation) and as of this consequence, due to the autophagy deregulation, this is said to cause immune dysfunction irregularities, cellular maturation incompatibilities and predispose to various autoimmune disorders and malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…Living cells and subsequently organisms obey specific laws of nature for existence [1]. Optimum ontogenesis, embryogenesis and morphogenesis function at growth rates of low entropy [1,2]. This low entropy offers the macromolecular structural existence that corresponds to an increase of degree of complexity that sustains life [2].…”

Section: Introductionmentioning

confidence: 99%

“…Optimum ontogenesis, embryogenesis and morphogenesis function at growth rates of low entropy [1,2]. This low entropy offers the macromolecular structural existence that corresponds to an increase of degree of complexity that sustains life [2]. However, optimality is finely balanced.…”

Section: Introductionmentioning

confidence: 99%

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Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

Kyriakopoulos¹,

McCullough

2021

Diseases

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The structure of synthetic mRNAs as used in vaccination against cancer and infectious diseases contain specifically designed caps followed by sequences of the 5′ untranslated repeats of β-globin gene. The strategy for successful design of synthetic mRNAs by chemically modifying their caps aims to increase resistance to the enzymatic deccapping complex, offer a higher affinity for binding to the eukaryotic translation initiation factor 4E (elF4E) protein and enforce increased translation of their encoded proteins. However, the cellular homeostasis is finely balanced and obeys to specific laws of thermodynamics conferring balance between complexity and growth rate in evolution. An overwhelming and forced translation even under alarming conditions of the cell during a concurrent viral infection, or when molecular pathways are trying to circumvent precursor events that lead to autoimmunity and cancer, may cause the recipient cells to ignore their differential sensitivities which are essential for keeping normal conditions. The elF4E which is a powerful RNA regulon and a potent oncogene governing cell cycle progression and proliferation at a post-transcriptional level, may then be a great contributor to disease development. The mechanistic target of rapamycin (mTOR) axis manly inhibits the elF4E to proceed with mRNA translation but disturbance in fine balances between mTOR and elF4E action may provide a premature step towards oncogenesis, ignite pre-causal mechanisms of immune deregulation and cause maturation (aging) defects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

Kyriakopoulos¹,

McCullough

2021

Diseases

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“…Modelling the average growth of a species in aquaculture systems for experimental or commercial purposes is essential to make predictions and measure its technical and economic performance. From a phenomenological perspective, the growth of living organisms results from the imbalance between the incoming flow of energy and the heat inside therein (Zotin & Pokrovskii, 2018). When this occurs, the system (body) enters a new state, while new internal processes emerge and the entropy of the system changes.…”

Section: Discussionmentioning

confidence: 99%

Determination of a predictive growth model for cultivated African catfish Clarias gariepinus (Burchell, 1882)

Musa

Hernández-Flores

Adeogun

et al. 2021

Aquaculture Research

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In recent years, aquaculture of the African catfish Clarias gariepinus (Burchell 1882) has experienced rapid growth in Africa, Asia and Europe. In order to improve its rearing systems, it is imperative to determine the individual growth patterns of the species. Individual fish growth is relevant when evaluating commercial viability, planning the time of harvest or projecting profits. In this study, we analysed the growth data of African catfish juveniles reared in an indoor freshwater recirculation aquaculture system and fed five different commercial aquafeeds over a period of 111 days. We fitted five nonlinear growth models—von Bertalanffy, Gompertz, Brody, Richards and logistic—to the weight data and applied the Akaike information criterion, the sum of squares and the maximum likelihood to determine the model that best describes the growth data of the species under the controlled culture conditions. According to the goodness‐of‐fit criteria, the Gompertz model was consistently the one that best described the growth of African catfish. The F‐test showed significant differences (p = 0.05) for one of the experimental feeds (T1,2) that produced the superior growth in terms of rate and biomass.

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“…34 The effects of nanoparticles on cells of living organisms depend on the diameter, size and shape of nanoparticles. 35 In this study, we introduced the synthesis of La 3+ /α-Al 2 O 3 nanoparticles with honey used as biocompatible capping agents using the ultrasound assisted hydrothermal method. Scheme 1 shows a summary of the experimental route for the synthesis of the La3+/α-Al2O3 NPs.…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly and Systematic Study for Synthesis of La3+/α-Al2O3 Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains

Moshafi

Ranjbar

Ilbeigi

2019

IJN

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Purpose: In this study, for the first time, new nanoparticles of La 3+ /α-Al 2 O 3 were synthesized with the ultrasonic-assisted hydrothermal method in the presence of honey as an ecofriendly and natural reagent. Methods: The as-synthesized La 3+ /α-Al 2 O 3 nanoparticles were characterized using scanning electron microscopy (SEM), transition electron microscopy (TEM), X-ray diffraction spectroscopy (XRD), energy dispersive X-ray (EDX), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. In this work, we report optimum conditions to synthesize La 3+ /α-Al 2 O 3 nanoparticles as novel material and as a candidate for antibacterial activity in antibacterial drugs. Results and Conclusion: The XRD and SEM micrograph results demonstrate the formation of pure La 3+ /α-Al 2 O 3 nanoparticles with a particle size in the range of 30-80 nm. The synthesis parameters were systematically examined using analysis of variance (ANOVA) through 2k −1 factorial design, and the factors were an assay for product optimization. Various factors such as hydrothermal time, temperature, ultrasound irradiation and interaction between these factors were investigated on the product size of the products. To investigate antibacterial activity of the La 3+ /α-Al 2 O 3 nanoparticles with the minimum inhibitory concentration (MIC) method, different dilutions of nanoparticles as 64,32,16,8,4, 2, 1 and 0.5 μg/mL were dissolved in dimethyl sulfoxide and diluted using distilled water and added to the Mueller-Hinton agar medium containing Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Serratia marcescens as gram-negative bacteria and Bacillus subtilis, Staphylococcus aureus, S. epidermidis and Micrococcus luteus as gram-positive bacteria.

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The growth and development of living organisms from the thermodynamic point of view

Cited by 10 publications

References 16 publications

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

Determination of a predictive growth model for cultivated African catfish Clarias gariepinus (Burchell, 1882)

<p>Eco-Friendly and Systematic Study for Synthesis of La<sup>3+</sup>/α-Al<sub>2</sub>O<sub>3</sub> Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains</p>

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