The aspects of uncertainty and complexity in which Ukrainian enterprises are forced to operate due to a full-scale military attack on the territory of Ukraine by a neighboring country are specified. The need for Ukrainian enterprises to specify the conditions for preserving and increasing their innovation and investment potential is substantiated, which should become a solid basis for long-term development in the post-war period. The main trends that are observed in the scientific field of Ukraine in the field of preservation and development of the innovation and investment potential of domestic business entities are analyzed. The reasons have been proven that should stimulate the management of modern enterprises to increase their own innovation and investment potential (increasing the competitiveness of the enterprise in the market; improving the reputation and strengthening the brand of enterprises in the market; increasing demand for products, sales volumes and income of the enterprise; increasing the attractiveness of the enterprise for investors; modernization production and increasing the professional competence of personnel, creating new jobs and increasing employment in the region, etc. The characteristics of innovation and investment activity and the corresponding potential of enterprises in Ukraine are given. The legislative and regulatory framework regulating the innovation and investment activity of enterprises in Ukraine is analyzed. Defined problematic aspects that reduce the possibilities for developing the innovative and investment potential of enterprises in Ukraine. Priority measures are proposed that will create favorable conditions for the innovative development of domestic enterprises in the post-war period. Such measures included the development of a mechanism for the practical implementation of incentive tools for enhancing the innovative development of an enterprise, declared in the regulatory framework of Ukraine; ensuring transparency and accessibility of information about investment opportunities; stimulation of scientific research at the state level; provision of preferential loans and grants for the implementation of innovative projects; implementation of a system of continuous professional development of personnel and search and development of talents at the enterprise.