We study elliptic curves over quadratic fields with isogenies of certain degrees. Let n be a positive integer such that the modular curve X 0 (n) is hyperelliptic of genus ≥ 2 and such that its Jacobian has rank 0 over Q. We determine all points of X 0 (n) defined over quadratic fields, and we give a moduli interpretation of these points. We show that, with finitely many exceptions up to Q-isomorphism, every elliptic curve over a quadratic field K admitting an n-isogeny is d-isogenous, for some d | n, to the twist of its Galois conjugate by a quadratic extension L of K; we determine d and L explicitly, and we list all exceptions. As a consequence, again with finitely many exceptions up to Q-isomorphism, all elliptic curves with n-isogenies over quadratic fields are in fact Q-curves.Mathematics Institute,