THE GUINEA‐PIG I‐REGION: III. DISTRIBUTION OF Ia ANTIGENS IN INBRED AND PARTIALLY INBRED STRAINS

Abstract

Summary We have used a combined serologic and structural approach to study the distribution of I‐region associated (Ia) antigens in nine strains of inbred and partially inbred guinea‐pigs. All of the inbred strains studied with the exception of strain 2 animals were found to share one or more I‐subregions with inbred strain 13 animals. The BIOAD, R9, OM3, and BIOAC strains have the same I‐region as strain 13 animals; the B/Lac strain has two subregions in common with strain 13, while the BIOB strain has a single subregion in common with strain 13. The availability of a number of different guinea‐pig strains with well characterized major histocompatibility complexes should facilitate the continuing use of this species in studies of immunogenetics, transplantation, and tumour immunology.

Immunochemical Evidence for Multiple Β Units of the Class Ii Molecule in the Rat

“…Thus, on the basis of cross-reactions of highly purified , B units with mouse alloantisera against I subregions, we have postulated that loci for the Ba-1 and Ba-3 molecules could be assigned to the I-A equivalent. Schwartz et al (1980) and Schevach et al (1980) postulated that guinea-pig I region can be divided into three subregions each containing an Ia locus which encodes an Ia antigen with a characteristic structure. A similar ,organization of class I1 antigens has been found in humans where HLA-DR, MB(MT-1, DC-1) and MT-3(BR4 x 7, Hon7) antigens were identified (Duquesnoy et al, 1979;Tosi et al, 1978;Katagiri et al, 1979;Park et al, 1980).…”