Facing the opportunities and challenges brought by the new scientific and technological revolution and industrial change nowadays, interdisciplinary development has become the inevitable trend in the future, and the construction of first-class interdisciplinary disciplines has definitely meet the country’s urgent need for high-quality talents in the new era. Based on the current situation of education and social development, this paper takes the graduate education of Northeast Asian Studies College of Jilin University as a case study. Aimed at the problems existing in the current economic management personnel training process, such as decoupling of positioning and demand, insufficient cross-disciplinary knowledge, limited combination of theoretical teaching and practical application, high barriers to cross-cooperation among teachers, and insufficient leading role of evaluation system, the paper analyzes how to construct the first-class interdisciplinary disciplines from the aspects of talent training positioning, curriculum system, practical teaching system, compound teachers team and comprehensive evaluation system. The purpose of this paper is to explore the training mode of graduate students in Economics, the formation mode of interdisciplinary teaching and the cultivation mode of high-quality research teams, to provide practical paths and countermeasures for the construction of first-class graduate discipline, and to make practical contributions to the construction of new liberal arts and the cultivation of high-level interdisciplinary talents.