The gut-brain vascular axis in neuroinflammation

Carloni, Sara; Rescigno, María

doi:10.1016/j.smim.2023.101802

Cited by 21 publications

(15 citation statements)

References 120 publications

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“…The gut-brain axis is a bidirectional communication pathway that signals information between the gut and the brain via the autonomic and enteric nervous system, the hypothalamic-pituitary axis, the vagal nerve, and systemic circulation [150,151]. Humans are exposed to millions of foreign substances referred to as xenobiotics directly and passively.…”

Section: Gut-brain Axis and Environmental Toxinsmentioning

confidence: 99%

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Ruggles,

Benakis

2024

Cells

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Recent evidence suggests that exposure to environmental toxins, both short-term and long-term, can increase the risk of developing neurological disorders, including neurodegenerative diseases (i.e., Alzheimer’s disease and other dementias) and acute brain injury (i.e., stroke). For stroke, the latest systematic analysis revealed that exposure to ambient particulate matter is the second most frequent stroke risk after high blood pressure. However, preclinical and clinical stroke investigations on the deleterious consequences of environmental pollutants are scarce. This review examines recent evidence of how environmental toxins, absorbed along the digestive tract or inhaled through the lungs, affect the host cellular response. We particularly address the consequences of environmental toxins on the immune response and the microbiome at the gut and lung barrier sites. Additionally, this review highlights findings showing the potential contribution of environmental toxins to an increased risk of stroke. A better understanding of the biological mechanisms underlying exposure to environmental toxins has the potential to mitigate stroke risk and other neurological disorders.

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Section: Gut-brain Axis and Environmental Toxinsmentioning

confidence: 99%

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Ruggles,

Benakis

2024

Cells

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“…Conversely, the presence of intestinal dysbiosis can lead to the development of chronic systemic inflammation, with notable effects on the brain, including an increased vulnerability to neuroinflammatory diseases like multiple sclerosis (MS) [119]. Recently, there has been growing recognition of the significance of the gut-brain axis in various neurological conditions, including strokes [120]. Of particular interest is the role of the microbiota in the progression of neurodegenerative diseases such as Alzheimer's and PD.…”

Section: Sleep and Microbiotamentioning

confidence: 99%

“…Of particular interest is the role of the microbiota in the progression of neurodegenerative diseases such as Alzheimer's and PD. Numerous studies have suggested that the intestine and its associated microbiota may contribute to the accumulation of amyloid fibers [120]. Additionally, α-synuclein, when accumulated in the gastrointestinal tract, has the potential to travel to the substantia nigra and striatum through the vagus nerve [121].…”

Section: Sleep and Microbiotamentioning

confidence: 99%

Sleep Pathologies and Eating Disorders: A Crossroad for Neurology, Psychiatry and Nutrition

Mutti,

Malagutti,

Maraglino

et al. 2023

Nutrients

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The intricate connection between eating behaviors and sleep habits is often overlooked in clinical practice, despite their profound interdependence. Sleep plays a key role in modulating psychological, hormonal and metabolic balance and exerting an influence on food choices. Conversely, various eating disorders may affect sleep continuity, sometimes promoting the development of sleep pathologies. Neurologists, nutritionists and psychiatrists tend to focus on these issues separately, resulting in a failure to recognize the full extent of the clinical conditions. This detrimental separation can lead to underestimation, misdiagnosis and inappropriate therapeutic interventions. In this review, we aim to provide a comprehensive understanding of the tangled relationship between sleep, sleep pathologies and eating disorders, by incorporating the perspective of sleep experts, psychologists and psychiatrists. Our goal is to identify a practical crossroad integrating the expertise of all the involved specialists.

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“…KEYWORDS: Microbiota; Mental ilnesess; Gut-Microbiota-Brain Axis. RESCIGNO, 2023, LUCZYNSKI et al, 2016POTHOULAKIS;MAYER, 2009).…”

Section: Considerações Finaisunclassified

Estratégia De Implantação De Um Programa De Educação Permanente De Uma Organização Social De Saúde Na Atenção Primária À Saúde: Um Relato De Experiência

Oliveira,

Nobre,

Pires

et al. 2023

Medicina: Competências Técnica, Cientifica E Ética Na Área Da Saúde 2

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The gut-brain vascular axis in neuroinflammation

Cited by 21 publications

References 120 publications

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Sleep Pathologies and Eating Disorders: A Crossroad for Neurology, Psychiatry and Nutrition

Estratégia De Implantação De Um Programa De Educação Permanente De Uma Organização Social De Saúde Na Atenção Primária À Saúde: Um Relato De Experiência

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