The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska, Beata; Gerkowicz, Agnieszka; Krasowska, Dorota

doi:10.1111/jdv.15951

Cited by 80 publications

(97 citation statements)

References 124 publications

(282 reference statements)

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“…The gut microbiome may contribute directly to alterations in the skin microbiome and the skin may be altering the gut microbiome—a newly emerging bidirectional signaling concept that has been labeled the “skin‐gut‐axis.” Alterations in the gut microbiome are directly correlated to clinically relevant changes in the manifestations of skin diseases such as psoriasis, atopic dermatitis, and acne . Although similar correlations have not yet been published for microbiomes of the gut and chronic skin wounds, several studies suggest that one may strongly influence the other.…”

Section: Parallel Mechanisms Between Gut‐brain‐axis and Skin‐brain Axismentioning

confidence: 99%

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Hadian

Fregoso

Nguyen

et al. 2020

Wound Repair Regeneration

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Chronic wounds cause a significant burden on society financially, medically, and psychologically. Unfortunately, patients with nonhealing wounds often suffer from comorbidities that further compound their disability. Given the high rate of depressive symptoms experienced by patients with chronic wounds, further studies are needed to investigate the potentially linked pathophysiological changes in wounds and depression in order to improve patient care. The English literature on wound healing, inflammatory and microbial changes in chronic wounds and depression, and antiinflammatory and probiotic therapy was reviewed on PubMed. Chronic wound conditions and depression were demonstrated to share common pathologic features of dysregulated inflammation and altered microbiome, indicating a possible relationship. Furthermore, alternative treatment strategies such as immune-targeted and probiotic therapy showed promising potential by addressing both pathophysiological pathways. However, many existing studies are limited to a small study population, a cross-sectional design that does not establish temporality, or a wide range of confounding variables in the context of a highly complex and multifactorial disease process. Therefore, additional preclinical studies in suitable wound models, as well as larger clinical cohort studies and trials are necessary to elucidate the relationship between wound microbiome, healing, and depression, and ultimately guide the most effective therapeutic and management plan for chronic wound patients.

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Section: Parallel Mechanisms Between Gut‐brain‐axis and Skin‐brain Axismentioning

confidence: 99%

Microbiome‐skin‐brain axis: A novel paradigm for cutaneous wounds

Hadian

Fregoso

Nguyen

et al. 2020

Wound Repair Regeneration

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“…An imbalanced gut microbiome, a pathological state named intestinal dysbiosis, has a negative impact on skin function and integrity [35,36]. O'Neill et al found that the gut microbiome can influence skin homeostasis via regulating the coordinate epidermal differentiation and immune system, although the mechanism is not yet fully elucidated [33].…”

Section: Gut Microbial and Skin-gut Axis In Psoriasismentioning

confidence: 99%

Gut–Brain–Skin Axis in Psoriasis: A Review

Chen

Zai-ming

Fan

et al. 2020

Dermatol Ther (Heidelb)

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Introduction Psoriasis is a common skin disease, with chronic inflammation and a complex etiology. It has long been recognized that chronic skin conditions and mental health disorders are often co-morbid. Thus, the concept of the gut–brain–skin axis emphasized in mental health disorders may also regulate the health of skin. Results The gut microbiota has been found to be the bridge between the immune system and nervous system. By leveraging clinical cases and animal models of psoriasis, an important communication pathway has been identified along the gut–brain–skin axis that is associated with the modulation of neurotransmitters from the microbiota. Furthermore, mammalian neurotransmitters, including dopamine, serotonin, or γ-aminobutyric acid (GABA), can be produced and/or consumed by several types of bacteria. Other studies suggest that manipulating these neurotransmitters by bacteria may have an effect on host physiology, and the levels of neurotransmitter can be altered by microbiota-based interventions. Conclusions Nonetheless, it is unknown whether or not the manipulation of neurotransmitter levels by bacteria can affect the occurrence and development of psoriasis. Notably, preliminary experiments found that oral consumption of probiotics improves the clinical symptoms in patients with psoriasis, perhaps correlated with the gut microbiome-mediated crosstalk between the immune system and the nervous system by secreting neurotransmitters in psoriasis. In this review, the communication along the gut–brain–skin axis is discussed.

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“…[5][6][7] In consequence, the role of the skin microbiome has become one of the major current frontiers of dermatological research. [8][9][10][11] However, compared with the extensively researched skin surface microbiome, [12][13][14][15][16] the specific microbiome of human hair follicles (HFs) has been relatively under-investigated, beyond pathogen-induced bacterial or fungal folliculitis, 17 hidradenitis suppurativa (HS), [18][19][20][21] folliculitis decalvans 22 and acne vulgaris. [23][24][25][26][27][28] Yet, a microbiome-centred perspective on translational human hair research is becoming ever more important, as hair growth disorders that had not previously been viewed from this perspective, such as alopecia areata (AA) 29,30 and androgenic alopecia, 31 have come under microbiological scrutiny.…”

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confidence: 99%