The gut microbiome modulates associations between adherence to a Mediterranean-style diet, abdominal adiposity, and C-reactive protein in population-level analysis

Jennings, Amy; Kühn, Tilman; Bondonno, Nicola P.; Waniek, Sabina; Bang, Corinna; Franke, Andre; Kassubek, Jan; Müller, Hans-Peter; Both, Marcus; Weber, Katharina S.; Lieb, Wolfgang; Cassidy, Aedín

doi:10.1016/j.ajcnut.2023.11.001

Cited by 6 publications

(1 citation statement)

References 45 publications

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“…Through the production of short-chain fatty acids, Porphyromonadaceae taxa might likely play a role as adiposity modulators ( Peng et al, 2009 ). To fulfill its function of safeguarding the gut and the human body, Jennings et al discovered that individuals with higher relative abundances of Porphyromonadaceae had lower levels of adipose tissue and systemic inflammation ( Jennings et al, 2023 ). Moreover, Valkonen et al observed that Family XI could provide protection against allergic illness by contrasting the intestinal flora of the healthy control group with that of allergic disease patients ( Valkonen et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study

Liu,

2024

Front. Microbiol.

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BackgroundAccumulating evidence suggests that alterations in gut microbiota composition are associated with the hidradenitis suppurativa (HS). However, the causal association between gut microbiota and HS remain undetermined.MethodsWe performed a bidirectional two-sample Mendelian randomization (MR) analysis using genome-wide association study summary data of gut microbiota and hidradenitis suppurativa from the MiBioGen consortium which concluded 18,340 individuals analyzed by the MiBioGen Consortium, comprising 211 gut microbiota. HS data were acquired from strictly defined HS data collected by FinnGenbiobank analysis, which included 211,548 European ancestors (409 HS patients, 211,139 controls). The inverse variance weighted method (IVW), weighted median (WME), simple model, weighted model, weighted median, and MR-Egger were used to determine the changes of HS pathogenic bacterial taxa, followed by sensitivity analysis including horizontal pleiotropy analysis. The MR Steiger test evaluated the strength of a causal association and the leave-one-out method assessed the reliability of the results. Additionally, a reverse MR analysis was carried out to seek for possible reverse causality.ResultsBy combining the findings of all the MR steps, we identified four causal bacterial taxa, namely, Family XI, Porphyromonadaceae, Clostridium innocuum group and Lachnospira. The risk of HS might be positively associated with a high relative abundance of Clostridium innocuum group (Odds ratio, OR 2.17, p = 0.00038) and Lachnospira (OR 2.45, p = 0.017) but negatively associated with Family XI (OR 0.67, p = 0.049) and Porphyromonadaceae (OR 0.29, p = 0.014). There were no noticeable outliers, horizontal pleiotropy, or heterogeneity. Furthermore, there was no proof of reverse causation found in the reverse MR study.ConclusionThis study indicates that Clostridium innocuum group and Lachnospira might have anti-protective effect on HS, whereas Family XI and Porphyromonadaceae might have a protective effect on HS. Our study reveals that there exists a beneficial or detrimental causal effect of gut microbiota composition on HS and offers potentially beneficial methods for therapy and avoidance of HS.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study

Liu,

2024

Front. Microbiol.

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Digesting the complex metabolic effects of diet on the host and microbiome

Carmody,

Varady,

Turnbaugh

2024

Cell

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A systematic review of observational studies on the association between diet quality patterns and visceral adipose tissue

Thimm,

Maskarinec,

Guillermo

et al. 2024

Br J Nutr

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Beyond obesity, visceral adipose tissue (VAT) has emerged as an important predictor of chronic disease, but the role of diet quality patterns (DQP) in VAT development is not well defined. Therefore, we conducted a systematic review of how various DQP are associated with VAT via literature searches in PubMed and EMBASE. We included observational investigations in disease-free adults/adolescents that related DQP to VAT assessed by imaging methods. The studies were evaluated separately for a priori and a posteriori DQP and according to design differences. Study quality was assessed using the Risk of Bias in Non-randomised Studies of Interventions tool. Of the 1807 screened articles, thirty-five studies met the inclusion criteria. The majority of a priori indices, for example, the Healthy Eating Index, showed significant inverse associations with VAT, while only a small proportion of a posteriori patterns were related to VAT. Results did not differ substantially by the method of exposure and outcome assessment or between studies with (n 20) or without (n 15) body-size adjustment, but significant findings were more common in younger v. older individuals, USA v. other populations and investigations with moderate v. serious risk of bias. The heterogeneity of the existing literature limited the ability to quantify the magnitude of the associations across studies. These findings suggest that a high-quality diet, as assessed by a priori DQP, is generally inversely associated with VAT, but results for a posteriori DQP are less consistent. As associations persisted after adjusting for body size, diet quality may beneficially influence VAT beyond its association with obesity.

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The gut microbiome modulates associations between adherence to a Mediterranean-style diet, abdominal adiposity, and C-reactive protein in population-level analysis

Cited by 6 publications

References 45 publications

Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study

Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study

Digesting the complex metabolic effects of diet on the host and microbiome

A systematic review of observational studies on the association between diet quality patterns and visceral adipose tissue

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