The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

Wang, Dong D.; Nguyen, Long H.; Li, Yanping; Yan, Yan; Ma, Wenjie; Rinott, Ehud; Ivey, Kerry L.; Shai, Iris; Willett, Walter C.; Hu, Frank B.; Rimm, Eric B.; Stampfer, Meir J.; Chan, Andrew T.; Huttenhower, Curtis

doi:10.1038/s41591-020-01223-3

Cited by 236 publications

(189 citation statements)

References 74 publications

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“…Regarding GM composition, P. copri can be responsible for the cardiovascular outcome of a Mediterranean diet, and, in particular, its abundance reduces CV protection [178]. Antioxidants play a fundamental role in health, and their introduction is necessary to prevent and treat or manage non-communicable diseases related to low-grade basal inflammation and dysbiosis, typical of conditions such as overweight or obesity.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation

et al. 2021

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It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome?

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation

et al. 2021

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“…Over the years, researchers have discovered that there are strong correlations between the gut microbiome and important systems in the human body, such as the brain in the nervous system and the immune system that protects the body against deadly infections and cancer ( Schwabe and Jobin, 2013 ; Gonzalez-Perez and Lamousé-Smith, 2017 ; Yang and Jobin, 2017 ; Chew et al, 2020 ; Johnson et al, 2020 ; Lee et al, 2021 ). Existing evidence has demonstrated that gut dysbiosis can contribute to the etiology of numerous human diseases, including diabetes, atherosclerosis, inflammatory bowel disease, atopic dermatitis, autism, or even the development of cancer ( Adlerberth et al, 2007 ; Michail et al, 2012 ; Morgan et al, 2012 ; Mulle et al, 2013 ; Vinje et al, 2014 ; Zackular et al, 2014 ; Song et al, 2016 ; Gózd-Barszczewska et al, 2017 ; Jie et al, 2017 ; Ni et al, 2017 ; Lee et al, 2020a , b ; Selvaraj et al, 2020 ; Wang et al, 2021 ). The process of how gut dysbiosis and certain microbial metabolites can lead to mucosal leakiness in the gut and promote inflammation milieu in the entire body by activating specific immune cells has been actively discussed over the past 10 years ( Chassaing et al, 2012 ; Nicholson et al, 2012 ; Tremaroli and Bäckhed, 2012 ; Chang et al, 2014 ; Joyce and Gahan, 2014 ; Lee and Hase, 2014 ; Vazquez-Castellanos et al, 2015 ; Marchesi et al, 2016 ; Rooks and Garrett, 2016 ).…”

Section: Importance Of Gut Microbiome In Diseasesmentioning

confidence: 99%

“…are natural inhabitants in the gut, some of them are now considered as pathobionts and linked with chronic inflammatory conditions ( Ley, 2016 ). For instance, Prevotella copri , as one of the “enterotypes” consistently detected in the gut microbiome, is frequently implicated in prompting metabolic changes and enhancing host susceptibility to gut mucosal inflammation ( Iljazovic et al, 2020 ; Wang et al, 2021 ). By manipulating the gut microbiome through diet, Wang and the team advocated the idea of using precision nutrition to restore the balance in the gut microbiome and consequently reducing the risk of cardiometabolic diseases ( Wang et al, 2021 ).…”

Section: Importance Of Gut Microbiome In Diseasesmentioning

confidence: 99%

“…For instance, Prevotella copri , as one of the “enterotypes” consistently detected in the gut microbiome, is frequently implicated in prompting metabolic changes and enhancing host susceptibility to gut mucosal inflammation ( Iljazovic et al, 2020 ; Wang et al, 2021 ). By manipulating the gut microbiome through diet, Wang and the team advocated the idea of using precision nutrition to restore the balance in the gut microbiome and consequently reducing the risk of cardiometabolic diseases ( Wang et al, 2021 ). In the same study, the team revealed a strong protective association between Mediterranean-style diet and cardiometabolic disease risk among a subgroup of the participants could be attributed to the absence of P. copri in their gut microbiomes.…”

Section: Importance Of Gut Microbiome In Diseasesmentioning

confidence: 99%

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The Use of Fecal Microbiome Transplant in Treating Human Diseases: Too Early for Poop?

et al. 2021

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Fecal microbiome transplant (FMT) has gained popularity over the past few years, given its success in treating several gastrointestinal diseases. At the same time, microbial populations in the gut have been shown to have more physiological effects than we expected as “habitants” of the gut. The imbalance in the gut microbiome or dysbiosis, particularly when there are excessive harmful pathogens, can trigger not just infections but can also result in the development of common diseases, such as cancer and cardiometabolic diseases. By using FMT technology, the dysbiosis of the gut microbiome in patients can be resolved by administering fecal materials from a healthy donor. The current review summarizes the history and current uses of FMT before suggesting potential ideas for its high-quality application in clinical settings.

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“…Mothers harbored more diverse microbial communities with many species characteristic of more complex diets such as Faecalibacterium prausnitzii and Prevotella copri (Fig. 1D) (13,14).…”

Section: Gut Bacteria Differed Taxonomically In Nipper Mothers and Their Infantsmentioning

confidence: 99%

Transcription shifts in gut bacteria shared between mothers and their infants: data from the NiPPeR Study

Vatanen

Sakwińska

Wilson

et al. 2021

Preprint

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The infant gut microbiome contains a portion of bacteria that originate from the maternal gut. In the infant gut these bacteria encounter a new metabolic environment that differs from the adult gut, consequently requiring adjustments in their activities. We utilized community RNA sequencing data (metatranscriptomes) from ten mother-infant dyads participating in the NiPPeR Study to characterize bacterial gene expression shifts following mother-to-infant transmission. Maternally derived bacterial strains adapted by large scale gene expression shifts following the transmission to the infant gut, with 12,564 activated and 14,844 deactivated gene families, including 1,007 transferases and 85 bacteriophage genes. The implicated genes were most numerous and the magnitude shifts greatest in Bacteroides spp. This study demonstrates environment-dependent, strain-specific shifts in gut bacteria function and underscores the importance of metatranscriptomic analysis in microbiome studies.

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The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

Cited by 236 publications

References 74 publications

Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation

Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation

The Use of Fecal Microbiome Transplant in Treating Human Diseases: Too Early for Poop?

Transcription shifts in gut bacteria shared between mothers and their infants: data from the NiPPeR Study

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