The gut microbiome: Potential innovations for the understanding and treatment of psychopathology.

Nowakowski, Matilda E.; McCabe, Randi E.; Rowa, Karen; Pellizzari, Joe; Surette, Michael G.; Moayyedi, Paul; Anglin, Rebecca

doi:10.1037/cap0000038

Cited by 6 publications

(6 citation statements)

References 80 publications

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“…Such an endeavour will be guided by psychological models of stress that capture factors such as individual differences (e.g., Mark & Smith, ) as well as dynamic processes such as coping mechanisms employed in response to stress (e.g., Skinner, Edge, Altman, & Sherwood, ). Evidence from laboratory animal models has also provided a rationale for examining the role of the gut microbiota in stress‐related disorders in humans, both in terms of differences between clinical groups and healthy controls, as well as whether changes within the gut may mediate amelioration of psychological disorder (e.g., Nowakowski et al, ). For example, evidence indicates that the gut microbiota is altered in patients with major depression (Jiang et al, ; Kelly, Borre, et al, ; Naseribafrouei et al, ), as well as IBS (see section below).…”

Section: Psychological Stress Host Physiology and The Gut Microbiommentioning

confidence: 99%

“…Evidence from laboratory animal models has also provided a rationale for examining the role of the gut microbiota in stress-related disorders in humans, both in terms of differences between clinical groups and healthy controls, as well as whether changes within the gut may mediate amelioration of psychological disorder (e.g., Nowakowski et al, 2016). For example, evidence indicates that the gut microbiota is altered in patients with major depression (Jiang et al, 2015;Kelly, Borre, et al, 2016;Naseribafrouei et al, 2014), as well as IBS (see section below).…”

Section: Psychological Stress Host Physiology and The Gut Microbimentioning

confidence: 99%

See 1 more Smart Citation

A psychology of the human brain–gut–microbiome axis

Allen

Dinan

Clarke

et al. 2017

Social & Personality Psych

136

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In recent years, we have seen increasing research within neuroscience and biopsychology on the interactions between the brain, the gastrointestinal tract, the bacteria within the gastrointestinal tract, and the bidirectional relationship between these systems: the brain–gut–microbiome axis. Although research has demonstrated that the gut microbiota can impact upon cognition and a variety of stress‐related behaviours, including those relevant to anxiety and depression, we still do not know how this occurs. A deeper understanding of how psychological development as well as social and cultural factors impact upon the brain–gut–microbiome axis will contextualise the role of the axis in humans and inform psychological interventions that improve health within the brain–gut–microbiome axis. Interventions ostensibly aimed at ameliorating disorders in one part of the brain–gut–microbiome axis (e.g., psychotherapy for depression) may nonetheless impact upon other parts of the axis (e.g., microbiome composition and function), and functional gastrointestinal disorders such as irritable bowel syndrome represent a disorder of the axis, rather than an isolated problem either of psychology or of gastrointestinal function. The discipline of psychology needs to be cognisant of these interactions and can help to inform the future research agenda in this emerging field of research. In this review, we outline the role psychology has to play in understanding the brain–gut–microbiome axis, with a focus on human psychology and the use of research in laboratory animals to model human psychology.

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Section: Psychological Stress Host Physiology and The Gut Microbiommentioning

confidence: 99%

Section: Psychological Stress Host Physiology and The Gut Microbimentioning

confidence: 99%

A psychology of the human brain–gut–microbiome axis

Allen

Dinan

Clarke

et al. 2017

Social & Personality Psych

136

View full text Add to dashboard Cite

show abstract

“…The human body consists of a number of microbial environments that are predominantly made up of bacteria, but also includes archaea, fungi, protists and viruses [1]. The intestinal or gut microbiome is the largest ecological community of the approximately 3.9 × 10 13 bacteria in the human body, nearly equal with the number of adult human cells [2], most of which are located in the distal gut and its genetic material outnumbers human DNA by 10-fold [3].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis

et al. 2022

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There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.

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“…This section provides a brief overview of some of the most frequently studied clinical conditions that sit at the intersection of psychological and microbial processes (for extensive reviews, see R. T. Liu, 2017; Nowakowski et al, 2016).…”

Section: Clinical Psychology and Psychopathologymentioning

confidence: 99%

Microbes and the Mind: How Bacteria Shape Affect, Neurological Processes, Cognition, Social Relationships, Development, and Pathology

Smith

Wissel

2019

Perspect Psychol Sci

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Recent data suggest that the human body is not so exclusively human after all. Specifically, humans share their bodies with approximately 10 trillion microorganisms, collectively known as the microbiome. Chief among these microbes are bacteria, and there is a growing consensus that they are critical to virtually all facets of normative functioning. This article reviews the ways in which bacteria shape affect, neurological processes, cognition, social relationships, development, and psychological pathology. To date, the vast majority of research on interactions between microbes and humans has been conducted by scientists outside the field of psychology, despite the fact that psychological scientists are experts in many of the topics being explored. This review aims to orient psychological scientists to the most relevant research and perspectives regarding the microbiome so that we might contribute to the now widespread, interdisciplinary effort to understand the relationship between microbes and the mind.

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The gut microbiome: Potential innovations for the understanding and treatment of psychopathology.

Cited by 6 publications

References 80 publications

A psychology of the human brain–gut–microbiome axis

A psychology of the human brain–gut–microbiome axis

Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis

Microbes and the Mind: How Bacteria Shape Affect, Neurological Processes, Cognition, Social Relationships, Development, and Pathology

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