2020
DOI: 10.3390/ijms21239239
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The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

Abstract: Breast cancer is the most frequently diagnosed cancer in women worldwide. The disease and its treatments exert profound effects on an individual’s physical and mental health. There are many factors that impact an individual’s risk of developing breast cancer, their response to treatments, and their risk of recurrence. The community of microorganisms inhabiting the gastrointestinal tract, the gut microbiota, affects human health through metabolic, neural, and endocrine signaling, and immune activity. It is thro… Show more

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Cited by 39 publications
(47 citation statements)
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References 170 publications
(336 reference statements)
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“…from primary bile acids [ 23 ]. It has been found to exert antitumor effects with a 10-20% decrease in breast cancer cell proliferation and inhibition of epithelial to mesenchymal cell transition [ 23 , 38 ]. It has antitumor immunity in murine models and in vitro, acting via the TGR5 receptor [ 23 , 38 ].…”
Section: Reviewmentioning
confidence: 99%
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“…from primary bile acids [ 23 ]. It has been found to exert antitumor effects with a 10-20% decrease in breast cancer cell proliferation and inhibition of epithelial to mesenchymal cell transition [ 23 , 38 ]. It has antitumor immunity in murine models and in vitro, acting via the TGR5 receptor [ 23 , 38 ].…”
Section: Reviewmentioning
confidence: 99%
“…It has been found to exert antitumor effects with a 10-20% decrease in breast cancer cell proliferation and inhibition of epithelial to mesenchymal cell transition [ 23 , 38 ]. It has antitumor immunity in murine models and in vitro, acting via the TGR5 receptor [ 23 , 38 ]. It also increases p53 expression, hence reducing cell death, and inhibits vascular endothelial growth factor (VEGF) production [ 23 - 24 , 38 ].…”
Section: Reviewmentioning
confidence: 99%
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