The gut microbiota and coronary artery calcification in Japanese men

Okami, Yukiko; Arima, Hisatomi; Kondo, Keiko; Hexun, Zhang; Yano, Yuichiro; Kadota, Aya; Torii, Sayuki; Hisamatsu, Takashi; Fujiyoshi, Akira; Kadowaki, Sayaka; Watanabe, Yoshiyuki; Andoh, Akira; Nakagawa, Yoshihisa; Ueshima, Hirotsugu; Miura, Katsuyuki

doi:10.1016/j.ahj.2023.09.009

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…However, the exact mechanism remains to be fully elucidated since the available investigations have only demonstrated a correlation between TMAO levels and endovascular calcification. A recent cross-sectional study in Japanese men that investigated the gut microbiota associated with CAC and CAD revealed that the composition of the gut microbiota was significantly different across taxonomic levels, from phylum to genus, and these were dependent on CAC scores, even before the onset of CAD [110]. This may open doors to finding novel prognostic gut biomarkers associated with the development of CAD and novel tools to track CAC progression [110].…”

Section: Association Between the Gut Microbiome And Cacmentioning

confidence: 99%

Beyond the Basics: Unraveling the Complexity of Coronary Artery Calcification

Hashmi,

Shah,

Aherrahrou

et al. 2023

Cells

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Coronary artery calcification (CAC) is mainly associated with coronary atherosclerosis, which is an indicator of coronary artery disease (CAD). CAC refers to the accumulation of calcium phosphate deposits, classified as micro- or macrocalcifications, that lead to the hardening and narrowing of the coronary arteries. CAC is a strong predictor of future cardiovascular events, such as myocardial infarction and sudden death. Our narrative review focuses on the pathophysiology of CAC, exploring its link to plaque vulnerability, genetic factors, and how race and sex can affect the condition. We also examined the connection between the gut microbiome and CAC, and the impact of genetic variants on the cellular processes involved in vascular calcification and atherogenesis. We aimed to thoroughly analyze the existing literature to improve our understanding of CAC and its potential clinical and therapeutic implications.

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Section: Association Between the Gut Microbiome And Cacmentioning

confidence: 99%