The haemagglutinin of Avibacterium paragallinarum is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities

Wang, Yiping; Hsieh, Ming-Kun; Tan, Duen-Huey; Shien, Jui-Hung; Ou, Shan-Chia; Chen, Chih‐Feng; Chang, Poa-Chun

doi:10.1016/j.vetmic.2014.10.013

Cited by 26 publications

(22 citation statements)

References 30 publications

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“…A genomic knockout of the type Vc transporter hemagglutinin of Avibacterium paragallinarum was created to study the function of the gene which is involved in hemagglutination, cell adherence, and biofilm formation (124). To study the mechanism of biofilm formation in Veillonella species, insertional inactivation of eight putative hemagglutinin genes was carried out using a tetracycline cassette.…”

Section: Deletion Of Mchb Completely Abolished Extracellular Secretiomentioning

confidence: 99%

Type V Secretion Systems in Bacteria

et al. 2016

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Type V secretion denotes a variety of secretion systems that cross the outer membrane in Gram-negative bacteria but that depend on the Sec machinery for transport through the inner membrane. They are possibly the simplest bacterial secretion systems, because they consist only of a single polypeptide chain (or two chains in the case of two-partner secretion). Their seemingly autonomous transport through the outer membrane has led to the term "autotransporters" for various subclasses of type V secretion. In this chapter, we review the structure and function of these transporters and review recent findings on additional factors involved in the secretion process, which have put the term "autotransporter" to debate.

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Section: Deletion Of Mchb Completely Abolished Extracellular Secretiomentioning

confidence: 99%

Type V Secretion Systems in Bacteria

et al. 2016

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“…Gene hmtp210 of A. paragallinarum encodes a 210-kDa outer-membrane protein that functions as an HA [ 18 ] and has been identified as an important protective antigen [ 12 ]. It has also been proposed that the HA antigen plays a key role in the pathogenicity of A. paragallinarum [ 20 ]. Wang et al .…”

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confidence: 99%

“…Wang et al . [ 20 ] showed that HA is a trimeric autotransporter adhesin that besides conferring hemagglutination, enables cell adherence and biofilm formation activities.…”

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confidence: 99%

Sequence analysis of the hypervariable region in <i>hmtp210</i> of <i>Avibacterium paragallinarum</i>

Araya-Hidalgo

Gutiérrez-Jiménez

Chaves-Ramírez

et al. 2017

The Journal of Veterinary Medical Science

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The hmtp210 gene of Avibacterium paragallinarum, the causative agent of infectious coryza, encodes an outer-membrane hemagglutinin (HA) that plays an essential role in pathogenicity. A hypervariable region within this HA, which is highly antigenic, is proposed as a candidate for recombinant vaccine production. Nonetheless, little is known about its genetic variability. We performed sequencing analysis of the hmtp210 hypervariable region in 16 clinical isolates from Costa Rica and compared them with 4 vaccine strains and the hmtp210 sequences available in public databases. Except for isolate ApCR12, all isolates showed high identity with reference vaccine strains 0083 and H18. Better genetic characterization of the hypervariable region of hmtp210 is necessary to develop better immunogenic strategies and improved molecular typing methods.

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“…Finally, vaccine development against animal pathogenic bacteria expressing TAAs is of high veterinary importance. For example, AhsA (designated according to gene locus ahsA) of Mannheima haemolytica A1, the principal cause of bovine pneumonic pasteurellosis, promotes colonisation and subsequent infection via its ability to bind collagen and, more importantly, is suggested to be immunogenic in calves [246]. Furthermore, the TAA HMTp210 is the major hemagglutinin antigen of Avibacterium paragallinarum, which can cause infectious coryza in poultry.…”

Section: Other Taasmentioning

confidence: 99%

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Thibau

Dichter

Vaca

et al. 2019

Med Microbiol Immunol

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The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.

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The haemagglutinin of Avibacterium paragallinarum is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities

Cited by 26 publications

References 30 publications

Type V Secretion Systems in Bacteria

Type V Secretion Systems in Bacteria

Sequence analysis of the hypervariable region in <i>hmtp210</i> of <i>Avibacterium paragallinarum</i>

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

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