The Haematological Features of Hiv Infection

Bain, Barbara J.

doi:10.1046/j.1365-2141.1997.2943111.x

Cited by 85 publications

(66 citation statements)

References 23 publications

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“…Similar to bone marrow aspirates, the bone marrow biopsies showed non-specific/reactive changes described in HIV-positive individuals (Ricci et al, 1995;Bain, 1997). In most cases, the marrow was hypercellular and the haematopoiesis showed disorganization with dysplastic features, which was most prominent in megakaryocytes.…”

Section: Bone Marrow Biopsy Features In MCD Casesmentioning

confidence: 64%

“…Although the features overlap with reactive/ dysplastic changes seen in HIV-infected patients (Bain, 1997;Brook et al, 1997), our results indicate that there are subtle morphological and immunohistochemical features that could be very helpful in the early diagnosis of this disease. The most significant changes were seen within the lymphoid component.…”

Section: Discussionmentioning

confidence: 76%

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Pathology of bone marrow in human herpes virus‐8 (HHV8)‐associated multicentric Castleman disease

Bacon¹,

Miller²,

Noursadeghi³

et al. 2004

Br J Haematol

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SummaryHuman herpes virus-8 (HHV8)-associated multicentric Castleman disease (MCD) is an unusual systemic lymphoid hyperplasia induced by HHV8-infected B cells. Most cases develop in the background of human immunodeficiency virus (HIV) infection. Despite the haematological problems at presentation and the difficulties in the initial diagnosis, the bone marrow appearances of MCD have not been described. In this study we examined the pathology of bone marrow in MCD with a view to identify the features that may be helpful in early diagnosis. Bone marrow aspirates and biopsies from 13 cases of MCD (11 of which were HIV+) and 66 control bone marrow biopsies from HIV-infected cases were studied. The specimens were routinely processed and stained. Immunohistochemistry for HHV8, immunoglobulin light chains, B-cell and plasma-cell markers was performed. The most important features were the presence of characteristic MCD lymphoid follicles containing HHV8+ plasmablasts in three of 13 cases of MCD and scattered interstitial HHV8+ plasmablasts in 11 of 13 cases. In control cases, no such follicles were seen and interstitial HHV8+ plasmablasts were rarely detected (four of 66 cases). Our results suggest that the presence of HHV8+ plasmablasts within lymphoid follicles and/or interstitium of the bone marrow are helpful features for the early diagnosis of MCD.

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Section: Bone Marrow Biopsy Features In MCD Casesmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 76%

Pathology of bone marrow in human herpes virus‐8 (HHV8)‐associated multicentric Castleman disease

Bacon¹,

Miller²,

Noursadeghi³

et al. 2004

Br J Haematol

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“…The virological, immunological and haematological parameters were studied as well as liver and renal functions. Anemia was the most frequent abnormality described, as reported in other studies [7] [8] [20] [21] [22]. The limitation of the study concerns the poor access to laboratory facilities in the provinces.…”

Section: Strengths and Limitationsmentioning

confidence: 56%

“…We found lower mean values for haemoglobin, haematocrit, mean cell count, leukocytes, polynuclear eosinophils and basophils and lymphocytes but higher blood creatinine, ALAT and ASAT values among patients with a low CD4 count. Immunological failure may be due to complications of opportunistic bacterial, viral, pa-rasitic or fungal infections or to the direct effect of the virus on certain haematopoietic progenitors, giving rise to anomalies in all cell lines [20]. Multiple ART and their secondary effects on patients' organ systems may be responsible for renal and hepatic lesions [21].…”

Section: Discussionmentioning

confidence: 99%

Biological Profile of HIV-Positive Patients in Bangui, Central African Republic, in 2017

Nyasenu¹,

Farra²,

Yambiyo³

et al. 2018

WJA

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Background: The biological profile of HIV-positive patients is essential for diagnosing treatment failure and the prognosis of infection. We determined the virological and immunological profiles and biological anomalies of HIV-positive people on antiretroviral therapy (ART) in Bangui, Central African Republic. Methods: We conducted an analytical, descriptive study between 4 April and 30 September 2017 of all patients who had received ART for more than 12 months and who attended the Medical Analysis Laboratory of the Institut Pasteur in Bangui for a complete biological work-up, including viral load. A blood sample was taken for quantification of RNA HIV-1, CD4 lymphocytes and blood count in two tubes containing ethylenediamine tetraacetic acid, and another sample was taken in a dry tube for measurement of creatinine and transaminases. Results: The total population comprised 1748 patients, with a mean age of 38.7 years (±14.3; median, 41 years; range, 2 -79 years); 33.3% of patients were between 40 and 49 years old. Females predominated (71.3%), for a sex ratio of 0.4. Immunological failure was observed in 20.2% of patients (CD4 < 200 cells/µL), and 44.5% of patients had a load of RNA HIV-1 ≥ 1000 copies/mL. The main haematological anomalies were anaemia (28.0%), leukopenia (26.7%), neutropenia (42.1%) and lymphopenia (27.2%). Blood creatinine was abnormal in 61.0% of patients, ALAT in 57.0% and ASAT in 66.9%. Conclusion: The abnormalities observed in this study concerned the haematopoietic system, the liver and the kidneys. As other organs and systems may be affected, periodic multidisciplinary biological and clinical follow-up is necessary for people living with HIV in order to improve their management.

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“…Riboflavin, folate, ascorbic acid, Zn and vitamin B 12 deficiencies are known to impair Hb synthesis. In addition to nutrient deficiencies, infections and parasites also contribute to anaemia; these include malaria, HIV infection and helminth infections (10)(11)(12) .…”

mentioning

confidence: 99%

Effect of combining multiple micronutrients with iron supplementation on Hb response in children: systematic review of randomized controlled trials

Gera

Sachdev

Nestel

2009

Public Health Nutr.

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Objectives: To study the effect of combining multiple (two or more) micronutrients with Fe supplementation on Hb response, when compared with placebo and with Fe supplementation, in children. Data sources: Electronic databases, personal files, hand search of reviews, bibliographies of books, and abstracts and proceedings of international conferences. Review methods: Randomized controlled trials evaluating change in Hb levels with interventions that included Fe and multiple-micronutrient supplementation in comparison to placebo alone or Fe alone were analysed in two systematic reviews. Results: Twenty-five trials were included in the review comparing Fe and micronutrient supplementation with placebo. The pooled estimate (random effects model) for change in Hb with Fe and micronutrient supplementation (weighted mean difference) was 0?65 g/dl (95 % CI 0?50, 0?80, P , 0?001). Lower baseline Hb, lower height-for-age Z score, non-intake of 'other micronutrients' and malarial non-hyperendemic region were significant predictors of greater Hb response and heterogeneity. Thirteen trials were included in the review comparing Fe and micronutrient supplementation with Fe alone. The pooled estimate for change in Hb with Fe and micronutrient supplementation (weighted mean difference) was 0?14 g/ dl (95 % CI 0?00, 0?28, P 5 0?04). None of the variables were found to be significant predictors of Hb response. Conclusions: Synthesized evidence indicates that addition of multiple micronutrients to Fe supplementation may only marginally improve Hb response compared with Fe supplementation alone. However, addition of 'other micronutrients' may have a negative effect. Routine addition of unselected multiple micronutrients to Fe therefore appears unjustified for nutritional anaemia control programmes.

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The Haematological Features of Hiv Infection

Cited by 85 publications

References 23 publications

Pathology of bone marrow in human herpes virus‐8 (HHV8)‐associated multicentric Castleman disease

Pathology of bone marrow in human herpes virus‐8 (HHV8)‐associated multicentric Castleman disease

Biological Profile of HIV-Positive Patients in Bangui, Central African Republic, in 2017

Effect of combining multiple micronutrients with iron supplementation on Hb response in children: systematic review of randomized controlled trials

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