The haemodilution enhanced onset of coagulation as measured by the thrombelastogram is transient

Abstract

The faster onset of coagulation brought on by haemodilution return towards normal as the dilutional effect is reversed. This effect is mediated through plasma clotting factors. Of interest is the significant inverse correlation of the onset of coagulation increasing as the antithrombin levels decreased with dilution.

Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples

“…This finding is consistent with a few previous reports [19][20][21][22][23] of the relationships of erythrocyte variables to results of TEG or TEM performed on blood samples from both humans and other animals. This finding is consistent with a few previous reports [19][20][21][22][23] of the relationships of erythrocyte variables to results of TEG or TEM performed on blood samples from both humans and other animals.…”

An Assessment of Clinical Interchangeability of TEG® and RoTEM® Thromboelastographic Variables in Cardiac Surgical Patients

“…Ruttmann et al demonstrated an increased coagulation profile with a shortening of the R and K times after dilution with normal saline. 14 Nielsen also found a shortening of the R time after dilution. 15 In the RoTEM ® system the blood is diluted by about 10%.…”

Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)*

“…These conflicting results may have been due to differences in the methods used in each of the studies, such as in vitro vs in vivo, animal vs human and healthy volunteers vs patients. Various conditions, such as the stress response to surgery [12, 18], activated coagulation due to tissue trauma [11, 19], and intra‐operative haemodilution [8, 20, 21] can increase blood coagulability in surgical patients. Prior in vitro or volunteer studies would not reflect these factors.…”