The Haemolytic, Icteric and Lipemic Sample Recommendations Regarding their Recognition and Prevention of Clinically Relevant Interferences. Recommendations of the Working Group on Preanalytical Variables of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine

Guder, W. G.; Fonseca-Wollheim, F. da; Heil, W.; Schmitt, Y.; Töpfer, G.; Wisser, H.; Zawta, B.

doi:10.1515/labm.2000.24.8.357

Cited by 23 publications

(19 citation statements)

References 27 publications

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“…6, B to D and F). There was no significant increase in hemolysis index [a spectrophotometric measure of plasma-free hemoglobin (23)] in LOM-treated or control animals (Fig. 6E).…”

Section: In Vivo Treatment Of Prolonged Asphyxiamentioning

confidence: 98%

Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery

et al. 2012

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We have developed an injectable foam suspension containing self-assembling, lipid-based microparticles encapsulating a core of pure oxygen gas for intravenous injection. Prototype suspensions were manufactured to contain between 50 and 90 ml of oxygen gas per deciliter of suspension. Particle size was polydisperse, with a mean particle diameter between 2 and 4 μm. When mixed with human blood ex vivo, oxygen transfer from 70 volume % microparticles was complete within 4 s. When the microparticles were infused by intravenous injection into hypoxemic rabbits, arterial saturations increased within seconds to near-normal levels; this was followed by a decrease in oxygen tensions after stopping the infusions. The particles were also infused into rabbits undergoing 15 min of complete tracheal occlusion. Oxygen microparticles significantly decreased the degree of hypoxemia in these rabbits, and the incidence of cardiac arrest and organ injury was reduced compared to controls. The ability to administer oxygen and other gases directly to the bloodstream may represent a technique for short-term rescue of profoundly hypoxemic patients, to selectively augment oxygen delivery to at-risk organs, or for novel diagnostic techniques. Furthermore, the ability to titrate gas infusions rapidly may minimize oxygen-related toxicity.

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“…6, B to D and F). There was no significant increase in hemolysis index [a spectrophotometric measure of plasma-free hemoglobin (23)] in LOM-treated or control animals (Fig. 6E).…”

Section: In Vivo Treatment Of Prolonged Asphyxiamentioning

confidence: 98%

Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery

et al. 2012

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“…If the lower confidence interval (CI) limit of the fold-change was lower than D min or the upper CI limit of the fold-change was above the D max , the difference was considered clinically significant. 17…”

Section: Interference Testingmentioning

confidence: 99%

Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis

et al. 2022

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“…Hemolysis can affect the quality of the specimen in three different ways. First, due to the higher intra-cellular concentration of some of the cell constituents, the rise of intracellular constituents in the extra-cellular space can undesirably increase the concentration of these analytes, such as potassium and lactat dehydrogenase (LDH) [ 16 ]. Second, the strong absorption of light linked to the presence of hemoglobin, affects the measurement of various analytes in clinical chemistry.…”

Section: Introductionmentioning

confidence: 99%

The „EPiQ“-Study (Evaluation of preanalytical quality): S-Monovette® in manual aspiration mode drastically reduces hemolytic samples in head-to-head study

Millius

Riedo

Caron

et al. 2021

Practical Laboratory Medicine

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Background Hemolytic blood samples are the number one cause for specimen rejection at emergency departments. Triggered by unsuitable blood sampling material or incorrect handling and a related strong vacuum force, hemolytic samples often must be retaken. The objective of this study was to assess whether correct manual aspiration using S-Monovette® could reduce the number of hemolytic samples. Methods Between January and April 2019, a head-to-head study was conducted. Whereas in the first eight weeks, all specimens were collected using Vacutainer®, in the second eight weeks, blood was taken using S-Monovette® in aspiration mode. Specimens were categorized into five classes (0–30, 31–50, 51–75, 76–100, and 101+ mg/dl of cell-free hemoglobin) and for the statistical analyses, all samples exceeding 30 mg/dl were classified as hemolytic. Results Data were collected on 4794 blood specimens (Vacutainer®: 2634 samples, S-Monovette®: 2160 samples). While the percentage of non-hemolytic samples (HI of 0–30 mg/dl) was substantially higher for specimens drawn by S-Monovette® (95.7 %) than Vacutainer® (83.0 %), the opposite was true for all HI categories above 30 mg/dl. Importantly, the reduction of hemolytic samples took place immediately following the imposition of S-Monovette® and remained stable at a low level until the end of the study. Conclusions Based on our results, we conclude that switching to S-Monovette® in manual aspiration mode in the blood sampling process could be highly beneficial, not only from a financial point of view, but also with regards to reducing unnecessary tasks and stress for nursing staff and improving patient outcome overall.

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The Haemolytic, Icteric and Lipemic Sample Recommendations Regarding their Recognition and Prevention of Clinically Relevant Interferences. Recommendations of the Working Group on Preanalytical Variables of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine

Cited by 23 publications

References 27 publications

Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery

Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery

Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis

The „EPiQ“-Study (Evaluation of preanalytical quality): S-Monovette® in manual aspiration mode drastically reduces hemolytic samples in head-to-head study

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