The Hair Follicle as a Wound Healing Promoter and Its Application in Clinical Practice

Jiménez, Francisco; Martínez, María Luisa Martínez; Escario, Eduardo; Izeta, Ander

doi:10.1002/9781119282518.ch12

Cited by 3 publications

(2 citation statements)

References 77 publications

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“…There have been several studies focused on the association between hair follicles and development of EPDS, and some authors focused on immunologic dysregulation toward the hair follicles induced by trauma with subsequent chronic inflammation [7]. Recently, another study revealed that a key histologic feature of EPDS is destruction of hair follicles [5], which act as a reservoir for keratinocytes and as wound healing promoters [6, 8]. Burn scar tissue is composed of hyalinized collagen and decreased elastic fibers, vessels, and adnexal structures [9].…”

Section: Discussionmentioning

confidence: 99%

Erosive Pustular Dermatosis of the Scalp Arising on Long-Standing Burn Scars: A Report of Three Cases and Brief Review of Literature

Kim,

Chae,

Lee

et al. 2023

Skin Appendage Disord

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Introduction: Erosive pustular dermatosis of the scalp (EPDS) is a rare and recalcitrant condition in which chronic scalp pustules and erosive patches are diagnosed by nondiagnostic laboratory tests and histopathological tests. Although various precipitating factors including trauma have been reported, erosive pustular dermatosis arising on the long-standing burn scars is rare. Case Presentation: We report three cases of EPDS arising on long-standing burn scars. Based on clinical and histological findings, erosive pustular dermatosis was diagnosed and successfully treated with topical steroid ointment. Conclusion: We propose that chronic burn scar is another precipitating factors for EPDS and clinicians should consider EPDS in differential diagnoses of erosive pustular dermatosis in long-standing burn scars on the scalp.

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Section: Discussionmentioning

confidence: 99%

Erosive Pustular Dermatosis of the Scalp Arising on Long-Standing Burn Scars: A Report of Three Cases and Brief Review of Literature

Kim,

Chae,

Lee

et al. 2023

Skin Appendage Disord

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“…LGR5 is recognized as a marker of HFSC in mice 8 , other stem cell markers such as SOX9, TCF4, LRIG1, LGR4 and LGR6, have also been linked to stem cell populations of the epidermis in mice and humans 22,32 . To examine whether LGR5+ HFSCs also express other stem cell markers, we used uorescence activated cell sorting (FACS) to separate the LGR5-high, low, and negative populations (Fig.…”

Section: Whilementioning

confidence: 99%

LGR5 is a Conserved Marker of Hair Follicle Stem Cells Across Species and is Present Early and Throughout Follicle Morphogenesis

Polkoff

Gupta

Green

et al. 2022

Preprint

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Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche and have remarkable regenerative capacity throughout hair cycling and display fate plasticity during cutaneous wound healing. Due to the need for a transgenic reporter, essentially all observations related to LGR5+ hair follicle stem cells have been generated using transgenic mice, which have significant differences in anatomy and physiology from the human. Using a transgenic pig model, a widely accepted model for human skin and human skin repair, we demonstrate that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development. We also report the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species. This information is important for understanding the fundamental differences and similarities across species, and ultimately improving human hair follicle regeneration, cutaneous wound healing, and skin cancer treatment.

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LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

Polkoff

Gupta

Green

et al. 2022

Sci Rep

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Hair follicle stem cells are key for driving growth and homeostasis of the hair follicle niche, have remarkable regenerative capacity throughout hair cycling, and display fate plasticity during cutaneous wound healing. Due to the need for a transgenic reporter, essentially all observations related to LGR5-expressing hair follicle stem cells have been generated using transgenic mice, which have significant differences in anatomy and physiology from the human. Using a transgenic pig model, a widely accepted model for human skin and human skin repair, we demonstrate that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development. We also report the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species. This information is important for understanding the fundamental differences and similarities across species, and ultimately improving human hair follicle regeneration, cutaneous wound healing, and skin cancer treatment.

show abstract

The Hair Follicle as a Wound Healing Promoter and Its Application in Clinical Practice

Cited by 3 publications

References 77 publications

Erosive Pustular Dermatosis of the Scalp Arising on Long-Standing Burn Scars: A Report of Three Cases and Brief Review of Literature

Erosive Pustular Dermatosis of the Scalp Arising on Long-Standing Burn Scars: A Report of Three Cases and Brief Review of Literature

LGR5 is a Conserved Marker of Hair Follicle Stem Cells Across Species and is Present Early and Throughout Follicle Morphogenesis

LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

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