2005
DOI: 10.1016/j.jsbmb.2005.01.009
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The hamster androgen receptor promoter: A molecular analysis

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Cited by 14 publications
(9 citation statements)
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“…At least three major transcription initiation sites, in an 18-base pair region located over 1-kilobase upstream the ATG translation initiation codon, have been identified in the human AR gene (8), while only two of these sites are observed in the mouse and rat (5,9). Studies in different species, including human (10), mouse (5), rat (9) and hamster (11) have revealed that the promoter region of AR gene lacks typical TATA and CAAT sequence motifs in the 5'-UTR, two common motifs that are recognized by components of the transcriptional machinery. It contains, however, a CG-rich region that is an important cis-acting element for AR gene transcription and a putative site that binds the constitutive active transcription factor Sp1.…”
Section: Androgen Receptor Gene and Protein Structurementioning
confidence: 99%
See 1 more Smart Citation
“…At least three major transcription initiation sites, in an 18-base pair region located over 1-kilobase upstream the ATG translation initiation codon, have been identified in the human AR gene (8), while only two of these sites are observed in the mouse and rat (5,9). Studies in different species, including human (10), mouse (5), rat (9) and hamster (11) have revealed that the promoter region of AR gene lacks typical TATA and CAAT sequence motifs in the 5'-UTR, two common motifs that are recognized by components of the transcriptional machinery. It contains, however, a CG-rich region that is an important cis-acting element for AR gene transcription and a putative site that binds the constitutive active transcription factor Sp1.…”
Section: Androgen Receptor Gene and Protein Structurementioning
confidence: 99%
“…It contains, however, a CG-rich region that is an important cis-acting element for AR gene transcription and a putative site that binds the constitutive active transcription factor Sp1. Multiple consensus sequences that recognize different transcription factors are also present in AR promoter region of different species, including AR itself, GR, ER, activating protein-1 (AP-1), cAMP responsive binding element (CREB), among others (9,11,12).…”
Section: Androgen Receptor Gene and Protein Structurementioning
confidence: 99%
“…Recently, in an animal model, reduced sensitivity to ER in breast cancer cells (MCF-7) isolated from lymph node metastases was found [41]. Since ERa downregulates AR expression [42], a reduced ER function in metastatic breast cancer cells could be a possible explanation for the higher AR expression encountered in node-positive patients. The strong independent prognostic value of charc-AR may be partly explained by its independence from MAI-10.…”
Section: Journal Of Surgical Oncologymentioning
confidence: 99%
“…ER did not interact with AR [30]. Furthermore, multiple consensus sequences in the hamster AR promoter region recognizes, as transcription factors, ER or AR itself [31].…”
Section: Discussionmentioning
confidence: 84%