The Hand and the Ipsilateral Primary Somatosensory Cortex: Figure 1.

Sutherland, Matthew T.

doi:10.1523/jneurosci.2698-06.2006

Cited by 18 publications

(20 citation statements)

References 8 publications

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“…Regarding the observation of bilateral activation of the hand representation in sensory cortex in response to unilateral hand-applied selfstimulation that was noted in the Results section for clitoral and vaginal self-stimulation, it is likely that the sensory stimulation emanating from that single hand, by utilizing the corpus callosum, gen-erates contra-as well as ipsi-lateral activation of the hand representation in sensory cortex. This observation is supported by substantial evidence in the literature of bilateral sensory cortical response to unilateral hand stimulation [21,22]. A more curious observation was the activation of the hand representation in sensory cortex during investigator-applied toe stimulation.…”

Section: Discussionmentioning

confidence: 61%

Women's Clitoris, Vagina, and Cervix Mapped on the Sensory Cortex: fMRI Evidence

Komisaruk

Wise

Frangos

et al. 2011

The Journal of Sexual Medicine

236

112

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Section: Discussionmentioning

confidence: 61%

Women's Clitoris, Vagina, and Cervix Mapped on the Sensory Cortex: fMRI Evidence

Komisaruk

Wise

Frangos

et al. 2011

The Journal of Sexual Medicine

236

112

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“…However, converging evidence from lesion studies, intracranial recordings, and fMRI results is consistent with activation of SI ipsilateral to the presentation of an innocuous cutaneous stimulus to the hand (for review, see Sutherland, 2006). Likewise, several recent fMRI studies using experimental noxious stimuli also suggest an ipsilateral or bilateral activation of SI associated with painful stimulation of the hand (Bornhovd et al, 2002;Bingel et al, 2004).…”

Section: Discussionmentioning

confidence: 78%

Memory Traces of Pain in Human Cortex

Albanese¹,

Duerden²,

Rainville³

et al. 2007

J. Neurosci.

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Distinct brain regions process sensory discriminative and affective components of pain; however, the role of these areas in pain memory is unknown. This event-related study investigated the short-term memory for sensory features of cutaneous heat pain using a delayeddiscrimination paradigm and functional magnetic resonance imaging. During memory trials, subjects discriminated the location and intensity of two painful stimuli presented sequentially to the right hand. Control trials comprised the same sequence of stimuli and motor responses but required no delayed discrimination. Stimulus-evoked activity for memory and control trials was generally indistinguishable within the network of regions normally responsive to experimental pain [i.e., the primary somatosensory cortex/posterior parietal cortex (SI/PPC), secondary somatosensory cortex (SII), and anterior insular cortex (aIC)]; these data confirm the painful nature of the stimuli and the similar levels of attention and stimulus encoding engaged during the two randomly presented trial types. Memoryspecific activity, assessed by contrasting the interstimulus interval in memory and control trials, was observed in SI/PPC and aIC but not in SII. We propose that SI/PPC plays a role in the short-term retention of spatial and intensity aspects of noxious stimuli and that aIC activation during memory trials is consistent with the integration of sensory and cognitive (attention, awareness, salience, and memory) components of pain perception. The absence of memory-specific anterior cingulate cortex activation, generally associated with pain unpleasantness, suggests that remembering affective aspects of the stimuli was not required during performance of the sensory delayeddiscrimination task.

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“…Interactions between ipsilateral and contralateral inputs in SI may derive from different anatomical pathways, which are not mutually exclusive (Sutherland, 2006). One first possibility is that ipsilateral somatosensory inputs are conveyed transcallosally from the contralateral SI (Allison, McCarthy, Wood, Williamson, & Spencer, 1989).…”

Section: Bilateral Representations Of the Body In Si And Siimentioning

confidence: 99%

“…However, neurophysiological studies in monkeys and neuroimaging works in humans have recently challenged the notion that neural representations of the body in SI are purely contralateral (e.g., Sutherland, 2006). In monkeys, bilateral receptive fields have been found within SI, in BA 1 and BA 2 (Keysers, Kaas, & Gazzola, 2010;Lipton, Fu, Branch, & Schroeder, 2006;Iwamura, Tanaka, Iriki, Taoka, & Toda, 2002;Iwamura, Taoka, & Iriki, 2001;Killackey, Gould, Cusick, Pons, & Kaas, 1983).…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Primary and Secondary Somatosensory Cortices to the Representation of Body Parts and Body Sides: An fMRI Adaptation Study

Tamè

Braun

Lingnau

et al. 2012

Journal of Cognitive Neuroscience

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Although the somatosensory homunculus is a classically used description of the way somatosensory inputs are processed in the brain, the actual contributions of primary (SI) and secondary (SII) somatosensory cortices to the spatial coding of touch remain poorly understood. We studied adaptation of the fMRI BOLD response in the somatosensory cortex by delivering pairs of vibrotactile stimuli to the finger tips of the index and middle fingers. The first stimulus (adaptor) was delivered either to the index or to the middle finger of the right or left hand, and the second stimulus (test) was always administered to the left index finger. The overall BOLD response evoked by the stimulation was primarily contralateral in SI and was more bilateral in SII. However, our fMRI adaptation approach also revealed that both somatosensory cortices were sensitive to ipsilateral as well as to contralateral inputs. SI and SII adapted more after subsequent stimulation of homologous as compared with nonhomologous fingers, showing a distinction between different fingers. Most importantly, for both somatosensory cortices, this finger-specific adaptation occurred irrespective of whether the tactile stimulus was delivered to the same or to different hands. This result implies integration of contralateral and ipsilateral somatosensory inputs in SI as well as in SII. Our findings suggest that SI is more than a simple relay for sensory information and that both SI and SII contribute to the spatial coding of touch by discriminating between body parts (fingers) and by integrating the somatosensory input from the two sides of the body (hands).

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The Hand and the Ipsilateral Primary Somatosensory Cortex: Figure 1.

Cited by 18 publications

References 8 publications

Women's Clitoris, Vagina, and Cervix Mapped on the Sensory Cortex: fMRI Evidence

Women's Clitoris, Vagina, and Cervix Mapped on the Sensory Cortex: fMRI Evidence

Memory Traces of Pain in Human Cortex

The Contribution of Primary and Secondary Somatosensory Cortices to the Representation of Body Parts and Body Sides: An fMRI Adaptation Study

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