The handheld blood lactate analyser versus the blood gas based analyser for measurement of serum lactate and its prognostic significance in severe sepsis

Abstract

m e d i c a l j o u r n a l a r m e d f o r c e s i n d i a 7 2 ( 2 0 1 6 ) 3 2 5 -3 3, and also, to analyze the prognostic significance of serum lactates and Simplified Acute Physiology Score 3 (SAPS 3) in patients of severe sepsis. Methods: 106 patients of severe sepsis admitted to the ICU were screened. The serum lactate from an arterial sample analyzed in both the machines was recorded at admission and at 48 h. These patients were then followed up to the 28th day for mortality. Results: The Lactate Pro LT 1710 handheld point of care lactate meter provides consistent results comparable to the Eschweiler Combiline blood gas analyser. Serum lactate concentration was significantly higher in nonsurvivors at the time of admission (3.30 AE 1.26) and at 48 h (4.34 AE 1.73). Lactate clearance at 48 h appears to be a better predictor of mortality than the lactate levels at 0 h and 48 h. The mean SAPS 3 at admission amongst survivors was significantly less as compared to nonsurvivors. The SAPS 3 had improved to 47.44 (AE11.79) in survivors at 48 h, while in nonsurvivors it had worsened to 81.98 (AE12.32) ( p = 0.00); thus, a worsening SAPS 3 at 48 h had a poorer prognosis. Conclusions: The Lactate Pro LT 1710 provides similar results to the Combiline Eschweiler blood gas analyser and is a cheaper alternative. It would prove to be a boon in peripheral hospitals in the aggressive management of critically ill patients. #

Exercise Oximetry Correlates Better With Exercise-Induced Lactate Increase, than Ankle Brachial Index or Walking Time, in Vascular Claudicants

“…The lactate ProÔ measures lactate on a blood drop of 5 μL. This hand-held device showed good correlation with the reference method in fetal blood, 19 and in adults in various environment 20 or critical care 21 conditions.…”

Biomarkers for Point-of-Care Diagnosis of Sepsis

“…This highlights an important factor that must be addressed when considering POCT; such testing must always be used in the appropriate clinical context, and the performance, limitations and cost (both in terms of outlay and potential cost savings) of the assay fully considered. Lactate may be measured on portable POCT devices and on blood-gas analysers equipped with a lactate-measuring electrode [118,119]. Blood-gas analysers are usually bench-top analysers that are generally not portable; however, they are routinely used in emergency departments, critical care environments and other hospital wards, as well as in central laboratories.…”

“…Their placement in such locations clearly designated them as POCT devices, despite their lack of portability. Hand-held devices incorporate similar measuring technology as the larger blood-gas analysers for measurement of lactate (direct ion-selective electrodes), and their performance is comparable to that of blood-gas analysers [118,119].…”

Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings

“…Separate point-of-care devices measuring blood lactate levels have been suggested as cheaper alternatives to blood gas analyzers in resourcelimited settings [189,211]. Moreover, availability of blood gas analyzers is severely limited [212], and contemporary evidence from resource-rich and resource-limited settings suggest that arterial blood gas measurement may not be necessary to diagnose and to improve outcomes for ARDS [137,213].…”