The Haplotype Analyses Using Multiple Markers of the Apolipoprotein B Gene in Patients with Coronary Artery Disease

Hong, Seung Ho; Song, Junghan; Kim, Jin Q

doi:10.3346/jkms.2001.16.6.719

Cited by 16 publications

(22 citation statements)

References 34 publications

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“…Combined genotypes or haplotypes for APOB polymorphisms consisting of some sites of the gene region have been described frequently in various ethnic populations (Renges et al 1992;De Benedictis et al 1993;Wu et al 1993;Hansen et al 1994;Hallman et al 1994;Anderson et al 1997;Hong et al 2001;Puri et al 2003). In comparison with the combined genotypes of four sites (AluI, XbaI, MspI, and EcoRI) in the Taiwanese (Wu et al 1993), the combined genotype frequencies of the Buryat differed significantly (P = 0.008).…”

Section: Discussionmentioning

confidence: 95%

“…Of the two most common combined genotypes (0000 and 1000), the frequency of 0000 was lower in the Buryat (56%) than in the Taiwanese (71%), and for 1000, no difference was recognized (28% vs. 21%). It has been shown that the frequency distribution of haplotypes at five sites (Ins/Del, AluI, XbaI, MspI, and EcoRI) in Koreans (Hong et al 2001) differs considerably from that of the Buryat. Despite the frequency of 67% of the haplotype code 00000 in the Buryat, the Koreans lacked it completely.…”

Section: Discussionmentioning

confidence: 98%

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Polymorphism of the Apolipoprotein B Gene and Association with Plasma Lipid and Lipoprotein Levels in the Mongolian Buryat

et al. 2011

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Allele frequencies at six RFLP sites (Ins/Del, ApaLI, AluI, XbaI, MspI, and EcoRI) of the apolipoprotein B gene (APOB) and the relationship of genotypes with plasma lipid and lipoprotein levels in the Mongolian Buryat were investigated. Common alleles at these sites in 110 Buryat subjects were I, G, A-, X-, M+, and E+; the frequencies of 0.809-0.991 differed strikingly from those of a few Asians and most Europeans. Five unambiguous haplotypes of all sites were revealed at 74%; haplotype IGA-X-M+E+ (000000) was the most frequent (67%), followed by IGA+X-M+E+ (001000) (19%). The frequency constitution differed significantly from the Chinese, Malaysians, and Caucasians but resembled the Indians. No APOB polymorphisms were associated with cholesterol levels (total, HDL and LDL). Significant associations of genotypes were shown with the triglyceride level only at the AluI and XbaI sites. The lipid level of A-A+ females or X-X+ males was higher than that of A-A- females or X-X- males, respectively.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Polymorphism of the Apolipoprotein B Gene and Association with Plasma Lipid and Lipoprotein Levels in the Mongolian Buryat

et al. 2011

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“…Furthermore, the distribution of different APOB haplotypes varies greatly in different populations. For example, the TT genotype (rare allele) frequency in the East Asian population (0.01-0.04) (Aburatani et al 1987;Hong et al 2001;Pan et al 1995;Wu et al 1994;Xu and Zhou 1998;Yan et al 2003;Ye et al 1995Ye et al , 1994Zang et al 2001;Zhang et al 2010Zhang et al , 2002 in our included studies was much lower than that in the Caucasian population (0.5) (Bohn et al 1993;Genest et al 1990;Hegele et al 1986), which may have caused the opposing results regarding its association with CAD/MI risk between the Caucasian and Asian populations.…”

Section: Discussionmentioning

confidence: 99%

“…The main characteristics of the included studies are listed in Table (1a, 1b, 1c, 1d, in Supplementary document). A total of 47 eligible studies (Aburatani et al 1987;Al-Bustan et al 2009;Anghebem-Oliveira et al 2009;Beneš et al 2000a, b;Berkinbayev et al 2014;Bohn et al 1993Bohn et al , 1994Buraczynska et al 2000;Corbo et al 1997;De Lorenzo et al 1993;de Padua Mansur et al 2000;Duman et al 2005;Dunning et al 1993;Ferns and Galton 1986;Gallegos-Arreola et al 2012;Gardemann et al 1998;Genest et al 1990;Hegele et al 1986;Hong et al 2001;Hosking et al 1992;Huang et al 2012;Kallel et al 2008;Machado et al 2001;Marshall et al 1994;Mendis et al 1991;Miettinen et al 1994;Myant et al 1989;Nieminen et al 1992;Pan et al 1995;Paulweber et al 1990;Rebhi et al 2008;Saha et al 1992;Salazar et al 2000;Scartezini et al 2003;Stepanov et al 1998;Tybjaerg-Hansen et al 1991;Visvikis et al 1993;Wiklund et al 1989;Wu et al 1994;Xu and Zhou 1998;…”

Section: Characteristics Of the Eligible Studiesmentioning

confidence: 99%

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

et al. 2015

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Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.Keywords Apolipoprotein B Á Polymorphism Á Coronary artery disease Á Myocardial infarction Á Meta-analysis Electronic supplementary material The online version of this article (

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“…17,18,45,46 The allelic variation of apo B gene polymorphisms may have some association with various ethnic groups. The EcoRI Rþ/Rþ genotype has been reported to occur most frequently among Koreans, 47 Japanese, 32 Caucasions, 33 and multiethnic Asian populations, 10 whereas the EcoRI RÀ/RÀ genotype has been shown to be the major genotype in Finns 34 and Caucasions generally. 48,49 In our study, the Rþ/Rþ genotype was found to be the highest in frequency when compared to Rþ/RÀ and RÀ/RÀ in both patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B gene variants are involved in the determination of blood glucose and lipid levels in patients with non-insulin dependent diabetes mellitus

Duman

Öztürk

Yılmazer

et al. 2006

Cell Biochem. Funct.

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We have examined the frequency of the EcoRI, XbaI and MspI RFLPs of the apolipoprotein B (apo B) gene in 110 type 2 diabetic patients and 91 healthy control subjects in order to ascertain whether variation in this gene may influence the development of non-insulin dependent diabetes mellitus (type 2 diabetes). Serum lipids including total-cholesterol (T-Chol), triacylglycerol (TAG), apolipoprotein E (apo E), apolipoprotein AI (apo AI), apolipoprotein B and lipoprotein (a) (Lp(a)) were analysed. Genomic DNA was extracted and the apo B polymorphic regions amplified by the polymerase chain reaction. Regions carrying EcoRI, XbaI, and MspI restriction sites present in the apo B gene were amplified and digested separately by the respective enzymes. No significant difference for genotypic frequencies was observed for the EcoRI, XbaI and MspI restriction sites in type 2 diabetic patients as compared to controls. Type 2 diabetic patients and controls with EcoRI +/+ and XbaI +/+ genotypes had higher apo E levels. The MspI +/+ genotype is more frequent in the patient and control groups with elevated T-Chol. Furthermore, the EcoRI -/-, XbaI -/-, and MspI +/+ genotypes were found to be significantly more frequent in type 2 diabetic patients with higher blood glucose levels. This study identifies the apo B gene polymorphisms in modulating plasma lipid/lipoprotein and glucose levels in patients with type 2 diabetes.

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The Haplotype Analyses Using Multiple Markers of the Apolipoprotein B Gene in Patients with Coronary Artery Disease

Cited by 16 publications

References 34 publications

Polymorphism of the Apolipoprotein B Gene and Association with Plasma Lipid and Lipoprotein Levels in the Mongolian Buryat

Polymorphism of the Apolipoprotein B Gene and Association with Plasma Lipid and Lipoprotein Levels in the Mongolian Buryat

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

Apolipoprotein B gene variants are involved in the determination of blood glucose and lipid levels in patients with non-insulin dependent diabetes mellitus

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