The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Abstract

Background: Corrosive esophageal burns have high morbidity and mortality. The effective treatment is controversial. In our study, we aimed to examine the effects of resveratrol (RSV) and platelet rich plasma (PRP) on healing in the corrosive esophagitis model in rats. 
 Material and methods: A total of 24 rats were randomly divided into 4 groups each as esophagitis, control, PRP and RSV groups. No treatment was administered to the control group. The esophagitis model was induced in the esophagitis and treatment groups. The esophagitis group was not treated. PRP group was treated with PRP, RSV group was treated with RSV. Pathological and biochemical examinations were performed from distal esophagitis. 
 Results: The highest tissue IL-1, IL-6, and TNF-α levels were observed in the esophagitis group. The lowest tissue IL-1, IL-6, and TNF-α levels were noted in the control group. The highest tissue TAS levels were observed in the control group. The lowest tissue TAS levels were noted in the esophagitis group. The other groups had significantly lower mean tissue TOS and OSI levels than the esophagitis group (P

The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury

“…Sun et al [55] studied xenograft tumors in the esophagus and found that gallic acid treatment reduced the volume of the esophageal carcinoma and Ki67 expression, a cell proliferation marker, via the Hippo signal pathway. Özden et al [56] investigated the roles of resveratrol in the corrosive esophagitis model and found that the total antioxidant status was increased, and the total oxidant status and levels of inflammation markers (IL1, IL6 and Tnfα) were decreased after resveratrol administration to rats. Another study showed that Carvacrol significantly restored the histopathology of CEB injury, induced re-epithelization, reduced apoptosis rate via downregulating the caspase-3 and reduced fibrosis [36].…”