The healing effect of the collagen-glycosaminoglycan copolymer on corneal thinning

Wu, Shu-Ya; Pan, Chien-Yi; Shen, Edward; Tzeng, I‐Shiang; Hsu, Wei-Cherng

doi:10.1186/s12886-018-0947-3

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Accordingly, results presented here in sham-operated eyes could be explained by the minimal tissue manipulation during surgery, which may potentially allow for a better recovery, when comparing the sham procedure with the intrableb implantation of the collagen matrix and the viscous solution of sodium hyaluronate. However, it is also important to consider that the collagen matrix implant itself might induce an inflammatory reaction even after the biomaterial is biodegraded, as previously reported by other authors [ 29 , 30 ]. That would also be in accordance with the inflammation reported for the treatment groups in comparison with sham-operated eyes.…”

Section: Discussionmentioning

confidence: 95%

The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model

et al. 2021

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Currently available anti-scarring treatments for glaucoma filtration surgery (GFS) have potentially blinding complications, so there is a need for alternative and safer agents. The effects of the intrableb administration of a new combination of the anti-VEGF bevacizumab, sodium hyaluronate and a collagen matrix implant were investigated in a rabbit model of GFS, with the purpose of modulating inflammation, angiogenesis, fibroblast migration and fibrogenesis in the wound healing process. A comparative-effectiveness study was performed with twenty-four rabbits, randomly assigned to the following treatments: (a) biodegradable collagen matrix implant (Olo), (b) bevacizumab-loaded collagen matrix implant (Olo-BVZ), (c) bevacizumab-loaded collagen matrix implant combined with sodium hyaluronate (Olo-BVZ-H5) and (d) sham-operated animals (control). Rabbits underwent a conventional trabeculectomy and were studied over 30 days in terms of intraocular pressure and bleb characterization (height, area and vascularity in central, peripheral and non-bleb zones). Histologic differences among groups were further evaluated at day 30 (inflammation, total cellularity and degree of fibrosis in the area of surgery). Local delivery of bevacizumab (Olo-BVZ and Olo-BVZ-H5) increased the survival of the filtering bleb by 21% and 31%, respectively, and generated a significant decrease in inflammation and cell infiltration histologically 30 days after surgery, without exhibiting any local toxic effects. Olo-BVZ-H5 showed less lymphocyte infiltration and inflammation than the rest of the treatments. Intraoperative intrableb implantation of bevacizumab, sodium hyaluronate and a collagen matrix may provide an improved trabeculectomy outcome in this model of intense wound healing. This study showed an effective procedure with few surgical complications and a novel combination of active compounds that offer new possibilities to improve the efficacy of filtration surgery.

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Section: Discussionmentioning

confidence: 95%

The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model

et al. 2021

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Histochemical and ultrastructural evaluation of myopic corneal lenticules based on refractive error

Oruz,

Şaker,

Şimşek

et al. 2024

Clinical Exper Ophthalmology

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BackgroundThis study aimed to investigate cell degeneration, apoptosis, and ultrastructural differences in refractive lenticules (RL) obtained using small incision lenticule extraction (SMILE) compared with spherical equivalence (SE) refraction values.MethodsThis study included 84 eyes from 42 patients. Patients were divided into two groups according to the SE values: those with values below 4 diopters (D) (Group 1) and above 4 diopters (D) (Group 2). Patients who did not belong to the same SE group were excluded from the study. One RL obtained from each patient was separated for light microscopy and immunohistochemical examinations, and another for transmission electron microscopy (TEM) examinations. Caspase‐3 for apoptosis and alpha‐smooth muscle actin (α‐SMA) for cell degeneration were evaluated using immunohistochemical examinations.ResultsHistological analyses showed that the density of collagen fibres was greater in Group 1 than in Group 2. Glycoaminoglycan and glycoprotein staining intensities were also higher in Group 1. TEM observations showed that Group 1 had intact cell and nuclear membranes, peripheral heterochromatin, and large nuclei, while Group 2 showed heterochromatin condensation and fragmentation, increased intracellular vacuoles, and loss of cytoplasm. Immunohistochemical analyses revealed that α‐SMA and caspase‐3 were significantly higher in Group 2 than in Group 1 (p < 0.001 and p < 0.001, respectively).ConclusionsCell degeneration and apoptosis were significantly more common in the RLs with high SE values after SMILE surgery. The tissue response induced by surgery was more severe in the RLs with high SE values. This should be considered when reusing RLs.

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FPLP3D: Security robot for face recognition in the workplace environment using face pose detection assisted controlled FACE++ tool position: A three-dimensional robot

Han

Zhang

Ning³

et al. 2021

WOR

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BACKGROUND: In recent years, several tracker systems have been developed to monitor a 3-dimensional skull position for facial action whereas, various tracker systems simultaneously analyze the single sequence of video, which can be provided with low-quality cameras and less security. Initially, implementing a 2-D face detector and an unrepentance system has been suggested; furthermore, it has been improved using an integrated 3-D face initialized scheme for the real-time tracker in the present face recognition systems. OBJECTIVES: To overcome the present setbacks of the conventional systems, Face Pose Detection assisted Controlled FACE++ tool position of Three-Dimensional Robot (FPLF3D) has been proposed in this article. Furthermore, the suggested proposed configuration has a high-end monitoring approach, which is used to improve the reliability of the robot’s human-machine contact in the workplace environment for security assistance. Additionally, the robot’s direction can be controlled by the operator’s head position assessment of the camera (or any active viewing system) using a three-dimensional robot. RESULTS: Besides, the Applications that are imitated by headers like telepresence, computer-generated reality, and video competitions will directly take advantage of the strategies introduced in this paper. CONCLUSION: Finally, Real video tests at the lab-scale level show the accuracy and usefulness of the approaches proposed in this research outperform the existing methods used for tracking.

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The healing effect of the collagen-glycosaminoglycan copolymer on corneal thinning

Cited by 3 publications

References 37 publications

The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model

The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model

Histochemical and ultrastructural evaluation of myopic corneal lenticules based on refractive error

FPLP3D: Security robot for face recognition in the workplace environment using face pose detection assisted controlled FACE++ tool position: A three-dimensional robot

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