2021
DOI: 10.21203/rs.3.rs-1092132/v1
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The Healing of Bone Defects by Cell-Free and Stem Cell-Seeded 3D Printed PLA Tissue Engineered Scaffolds

Abstract: One of the main issues in bone tissue engineering is to realize the response of the host to the engineered scaffolds. In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D printed PLA scaffolds was studied in rat calvaria bone. First, the scaffolds were 3D printed based on a designed computer model and half of them were seeded by with bone marrow-derived mesenchymal stem cells (BMSCs). The SEM images of the surfaces of PLA and PLA+Cell scaffolds were taken for m… Show more

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