The health impact of nonoccupational exposure to asbestos: what do we know?

Goldberg, Marcel; Luce, Danièle

doi:10.1097/cej.0b013e32832f9bee

Cited by 64 publications

(50 citation statements)

References 95 publications

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“…Until now, asbestos is the only established risk factor for mesothelioma (except for erionite fibers but these are not present in France). However, in the two studies only occupational asbestos exposure were considered, and domestic or environmental asbestos exposure could have been a possible confounding factor [26].…”

Section: Resultsmentioning

confidence: 99%

Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Lacourt¹,

Rolland²,

Gramond³

et al. 2010

Eur J Epidemiol

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Pleural mesothelioma is a primary tumor of the pleura that is mainly due to asbestos exposure. To study the relationship between mesothelioma and occupational asbestos exposure in France, two case-control studies (A and B) were conducted. A substantial difference in the attributable risk in the population (AR p ) was observed among men: 44.5% (95% CI: [32.6 -56.4]) in study .6]) in study B. As different exposure assessment expert methods were used, the main objective of this work was to re-estimate the ARp among men in two case-control studies according to a common standardized exposure assessment by using a Job Exposure Matrix (JEM) and to assess the role of subjects" selection. The initial observed AR p difference was maintained:36.3% (95% CI: [24.3 -50.3]) in study A and 69.7% (95% CI: 51.7 -83.2]) in study B. Further investigations highlighted the potential selection bias introduced in both studies, especially among controls. The AR p could be underestimated in study A and overestimated in study B. After weighting subjects according to distribution of socio-economic status in the general population for controls and according to distribution of socio-economic status of cases registered by the French National Mesothelioma Surveillance Program, re-estimated AR p values were 52.4% in study A and 70.2% in study B. These results provide additional information to describe the relationship between pleural mesothelioma and occupational asbestos exposure, but also confirm the importance of subjects" recruitment in case control studies, particularly control selection. KEY WORDSAsbestos, attributable risk, case-control study, men, mesothelioma, occupational exposure.

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Section: Resultsmentioning

confidence: 99%

Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Lacourt¹,

Rolland²,

Gramond³

et al. 2010

Eur J Epidemiol

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“…A recent review reported evidence of an increased risk of pleural mesothelioma among subjects reporting para-occupational or domestic asbestos exposure, and among subjects living near an industrial asbestos source (mines, mills, and asbestosprocessing plants) [Goldberg and Luce, 2009]. A metaanalysis estimated the relative risks of pleural mesothelioma related to environmental and domestic asbestos exposure at 7.0 [95% confidential interval, CI 4.7-11.0] and 8.1 .0], respectively [Bourdes et al, 2000].…”

Section: Introductionmentioning

confidence: 98%

Characterization of a French series of female cases of mesothelioma

Camiade

Gramond

Jutand

et al. 2013

American J Industrial Med

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“…In Europe there are asbestos deposits in Italy, Greece and Cyprus [4] [ [29][30][31][32][33]. Asbestos is a non-flammable material and has a great mechanical endurance.…”

Section: Pathophysiologymentioning

confidence: 99%

Malignant Pleura Mesothelioma: Clinical Perspectives

Grapatsas¹,

Leivaditis²,

Dahm³

et al. 2017

Oncomedicine

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Malignant pleural mesothelioma (MPM) is a primary health issue which preoccupies the health professional community worldwide. The main cause of the disease is the environmental exposure to asbestos. Because of the lack of relevant symptomatology, the disease is usually diagnosed at an advanced stage. Despite the progress in the therapeutic means, the mortality of the disease remains high. Τhe optimal approach to the disease consists of the preventive efforts to remove asbestos materials, the early diagnosis and proper early therapeutic treatment. Despite the fact that new cases of MPM are diagnosed, it is believed that the incidence of the disease is declining. In this study an overview of the epidemiology, etiology, mechanisms of pathophysiology and symptomatology of MPM is carried out.

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The health impact of nonoccupational exposure to asbestos: what do we know?

Cited by 64 publications

References 95 publications

Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Characterization of a French series of female cases of mesothelioma

Malignant Pleura Mesothelioma: Clinical Perspectives

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