“…Several studies taken from both clinical and general population samples (with sample sizes ranging from 89 to 4123 autistic participants) suggest that autistic individuals are less likely to smoke, use tobacco, use nicotine, 11 , 12 , 13 or misuse substances (including alcohol) than non-autistic individuals. 12 , 13 , 14 , 15 , 16 By contrast, results from larger studies and one systematic review indicate that autistic individuals might have an increased likelihood of developing substance use-related problems. 17 , 18 , 19 , 20 Specifically, in large population-based studies in Sweden (including 26 986 autistic individuals) and Norway (including 7528 autistic individuals), autistic individuals were twice as likely to have substance use problems than non-autistic individuals; and even their non-autistic siblings and parents were at increased risk of substance use problems compared with controls, suggesting that genetic or environmental factors might contribute to risks.…”