The health outcomes of inflammation and obesity in patients with heart failure

Saleh, Zyad T.; Lennie, Terry A.; Darawad, Muhammad W.; Alduraidi, Hamza; Elshatarat, Rami A.; Almansour, Issa M.; Moser, Debra K.

doi:10.1016/j.hrtlng.2020.05.010

Cited by 7 publications

(10 citation statements)

References 34 publications

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“…Most participants were in New York Heart Association functional class I or II (57%), had HF with reduced left ventricular ejection fraction (80%) and ischemic etiology of HF (62%), and were on angiotensin-converting enzyme inhibitors (79%), β-blocker (90%), diuretics (89%), antidyslipidemia (87%), and aspirin (61%) medications. The average HF duration was 4 years (range, 1-9 years), and the comorbidity score was 2.3 (range, [1][2][3][4][5][6][7][8][9][10][11]. Approximately half of the participants were obese.…”

Section: Resultsmentioning

confidence: 99%

“…1,3,4 Despite optimal medical therapy to slow the progression of HF, patients continue to experience persistent or worsening HF symptoms. 1,2,5,6 Current guidelines indicate the need to incorporate comprehensive lifestyle modifications into the ongoing medical therapy immediately after the diagnosis of HF to decrease progression and symptom severity. 1,2,7 Clinical trials show that exercise training decreases HF symptoms, improves quality of life, prolongs survival, and lowers hospitalization rates.…”

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confidence: 99%

“…These symptoms are associated with greater HF severity and poor prognosis and are considered the primary reasons for recurrent rehospitalizations and decreased health-related quality of life 1,3,4 . Despite optimal medical therapy to slow the progression of HF, patients continue to experience persistent or worsening HF symptoms 1,2,5,6 . Current guidelines indicate the need to incorporate comprehensive lifestyle modifications into the ongoing medical therapy immediately after the diagnosis of HF to decrease progression and symptom severity 1,2,7 …”

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confidence: 99%

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Effect of a Home-Based Mobile Health App Intervention on Physical Activity Levels in Patients With Heart Failure

et al. 2022

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Background: The use of mobile health applications (apps) is an effective strategy in supporting patients' self-management of heart failure (HF) in home settings, but it remains unclear whether they can be used to reduce sedentary behaviors and increase overall physical activity levels. Aim: The aims of this study were to determine the effect of an 8-week home-based mobile health app intervention on physical activity levels and to assess its effects on symptom burden and health-related quality of life. Method: In this study, we collected repeated-measures data from 132 participants with HF (60.8 ± 10. 47 years) randomized into a usual care group (n = 67) or an 8-week home-based mobile health app intervention group (n = 65). The intervention was tailored to decrease the time spent in sedentary behavior and to increase the time spent in physical activities performed at light or greater intensity levels. Physical activity levels were monitored for 2 weeks before the intervention and during the 8-week intervention using the Samsung mobile health app. Heart failure symptom burden and health-related quality of life were assessed at baseline, 2 weeks from baseline assessment, and immediately post intervention. Results: At week 8, all participants in the intervention group demonstrated an increase in the average daily step counts above the preintervention counts (range of increase: 2351-7925 steps/d). Only 29 participants (45%) achieved an average daily step count of 10000 or higher by week 6 and maintained their achievement to week 8 of the intervention. Repeated-measures analysis of variance showed a significant group-by-time interaction, indicating that the intervention group had a greater improvement in physical activity levels, symptom burden, and health-related quality of life than the usual care group. Conclusion: Home-based mobile health app-based interventions can increase physical activity levels and can play an important role in promoting better HF outcomes.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Effect of a Home-Based Mobile Health App Intervention on Physical Activity Levels in Patients With Heart Failure

et al. 2022

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“…Others proposed that inflammatory markers are better indicators of outcomes in HF. 13 The prevalence of adult obesity increased from 30.5% in 1999-2000 to 42.4% in 2017-2018. The prevalence of severe obesity (body mass index [BMI] ≥ 40 kg/m 2 ) almost doubled in 2017-2018 (9.2%), compared with 1999-2000 (4.7%).…”

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confidence: 99%

“…Marcks and colleagues 12 reported that obesity is a marker of less advanced disease, rather than having independent cardioprotective effects in HF. Others proposed that inflammatory markers are better indicators of outcomes in HF 13 . The prevalence of adult obesity increased from 30.5% in 1999–2000 to 42.4% in 2017–2018.…”

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confidence: 99%

Obesity-Related High-Output Heart Failure

et al. 2022

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Background: High-output heart failure (HF) is a type of HF characterized by signs and symptoms of HF and a cardiac output of 8 L/min or greater or a cardiac index greater than 3.9 L/min/m 2 . High-output HF occurs secondary to an underlying condition that requires high cardiac output due to an increase in oxygen consumption or decreased systemic vascular resistance. Obesity is a major cause of high-output HF, yet there is limited research on obesity-related high-output HF. Thus, the pathophysiologic mechanisms of this syndrome are not fully understood. Objective: The objectives of this integrative review were to describe the current state of the research regarding obesity-related highoutput HF and to recommend direction for future research. Methods: We conducted an integrative review focusing on the peer-reviewed literature on patients with obesity-related high-output HF using Whittemore and Knafl's methodology. MEDLINE, CINAHL, and EMBASE electronic databases were searched for all publications indexed in the databases as of March 9, 2022. A narrative synthesis of definitions and symptoms, obesity as an underlying condition, pathophysiology, and treatments of obesity-related high-output HF was completed. Results: A total of 6 articles were included in the integrative review, with 1 nonexperimental, retrospective study and 5 literature reviews. Understanding of obesity-related high-output HF is very limited because of scant empirical evidence in the existing literature. Possible pathophysiologic mechanisms include increased pressure in the upper airways, adipokine dysregulation, increased metabolic activity, and insulin resistance. Conclusion: Additional research is needed on the pathophysiologic mechanisms of obesity-related high-output HF to begin investigations on therapeutic interventions to improve health outcomes.

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