Based on the stimulus-organism-response theory and cognitive-affective personality system theory, this paper explores how the theoretical model of the workplace safety climate (WSC) influences presenteeism. Affect-based trust and cognition-based trust are assessed, and the situational role of organization formalization is examined. Using a time-lagged research design, data from 396 healthcare employees were gathered and multiple regression and bootstrapping were used to test each hypothesis. The results show that: (1) WSC significantly reduces presenteeism. (2) Both affect-based trust and cognition-based trust mediate the relationship between WSC and presenteeism. Affect-based trust exerts a complete mediating role, while cognition-based trust exerts a partial mediating role. (3) Cognition-based trust completely mediates the relationship between affect-based trust and presenteeism. (4) Organization formalization exerts a positive moderating effect on the relationship between WSC and affect-based trust. However, it exerts no significant moderating effect on the relationship between WSC and cognition-based trust. This study overcame the single research perspective. Combined with organizational, work-related, and person-related factors, the internal logic of the impact of WSC on the decision-making process in presenteeism was identified.The research results provide practical information for enterprises to create a sustainable organizational environment, reduce risks related to human resources, and effectively manage organizational health.Sustainability 2020, 12, 2414 2 of 17 attention from academic scholars and practitioners in organizational health and human resources management [1].Presenteeism has become a common phenomenon in developed Western societies [10,11]. Caused by the cultural requirements to work hard and show perseverance, compared with Western employees, Chinese employees are more likely to work despite being ill [12,13]. Previous studies on presenteeism confirmed that job insecurity affects both the work behaviors and decisions of employees [3,5]. However, few studies have explored variables that were less proximal to the workplace such as environmental factors [1]. Sustainable psychology emphasizes the importance of creating a sustainable organizational environment that promotes employee health and well-being [14]. Workplace safety climate (WSC) is a typical safety-related organizational environment that positively correlated with safety outcomes [15]. The safety climate literature has examined the link between WSC and safety outcomes such as improve safety motivation, compliance with safe working behaviors, reduce injuries and accidents, promote safety performance [16,17]. According to previous study, the definition of WSC refers to safety management priorities, systems, practices, and procedures to reward, support, and persuade employees to behave safely in the present study [18]. This study aims to explore the internal mechanisms between WSC and presenteeism.Stimulus-organism-response (SOR) theor...